微卫星不稳定性在泌尿系统及妇科肿瘤中的研究进展  

Research Progress on Microsatellite Instability in Tumors of the Urinary System and Gynecological System

作　　者：王睿宇 侯一夫 冉清 WANG Ruiyu;HOU Yifu;RAN Qing(Department of Organ Transplantation,the Affiliated Hospital of University of Electronic Science and Technology of China Sichuan Provincial People's Hospital,Chengdu 610072,China)

机构地区：[1]电子科技大学附属医院、四川省人民医院器官移植中心,成都610072

出　　处：《临床误诊误治》2024年第10期92-100,共9页Clinical Misdiagnosis & Mistherapy

基　　金：四川省干部保健科研课题(2023-211)。

摘　　要：随着在越来越多的肿瘤中发现微卫星不稳定性(MSI)/错配修复缺陷存在,以及针对MSI阳性肿瘤患者的一类特殊免疫治疗药物——抗程序性死亡受体1或程序性死亡受体配体1免疫检查点抑制剂的使用,MSI已经成为预测肿瘤预后以及指导免疫治疗的一个非常重要的指标。本文主要综述MSI的发生机制、检测方法及其在泌尿系统、妇科常见肿瘤中的研究进展,为后续MSI的进一步研究提供参考。With the discovery of microsatellite instability(MSI)/mismatch repair defect(dMMR)in an increasing number of tumors,and the use of a special class of immunotherapy drugs for patients with MSI-positive tumors:anti-programmed death receptor 1 or programmed death receptor ligand 1 immune checkpoint inhibitors,MSI has become a very important indicator for predicting tumor prognosis and guiding immunotherapy.This article mainly reviews the pathogenesis,detection methods and research progress of MSI in common tumors of urinary system and gynecology,so as to provide reference for further research on MSI.

关 键 词：微卫星不稳定性 尿路上皮癌 膀胱癌 前列腺癌 肾癌 子宫内膜癌 卵巢癌 宫颈癌 综述 

分 类 号：R737[医药卫生—肿瘤]