霍奇金淋巴瘤相关抗代谢型谷氨酸受体5脑炎1例  

A case of anti-metabotropic glutamate receptor 5 encephalitis associated with Hodgkin′s lymphoma

作　　者：常琳 范思远[1] 任海涛[1] 李佳[1] 关鸿志 Chang Lin;Fan Siyuan;Ren Haitao;Li Jia;Guan Hongzhi(Department of Neurology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Beijing 100730,China;Department of Gerontology,Beijing Aerospace General Hospital,Beijing 100076,China)

机构地区：[1]中国医学科学院北京协和医学院北京协和医院神经科,北京100730 [2]北京航天总医院老年医学科,北京100076

出　　处：《中华神经科杂志》2024年第6期639-641,共3页Chinese Journal of Neurology

摘　　要：抗代谢型谷氨酸受体5(mGluR5)脑炎为一种罕见的自身免疫性脑炎。现报道1例抗mGluR5脑炎病例。患者为青年男性,既往霍奇金淋巴瘤病史,因肿瘤复发而使用检查点免疫抑制剂治疗,之后出现发热、头痛、精神行为异常、记忆力下降、意识障碍、癫痫发作等脑炎症状,血清抗mGluR5抗体阳性,经过激素、丙种球蛋白等治疗后症状好转。Metabotropic glutamate receptor 5(mGluR5)encephalitis is a rare type of anti-cell surface antigen antibody encephalitis mediated by autoimmune mechanisms.This article reported a case of anti-mGluR5 encephalitis.The patient was a 25-year-old young man with a history of Hodgkin′s lymphoma.Due to tumor recurrence,he developed encephalitis symptoms including fever,headache,mental and behavioral abnormalities,memory loss,consciousness disturbance,and seizures after checkpoint immunosuppressive therapy.He was finally diagnosed as anti-mGluR5 encephalitis by positive serum anti-mGluR5 antibodies.Finally,the symptoms alleviated after treatment with hormones and gamma globulin.

关 键 词：副肿瘤综合征 神经系统 霍奇金病 抗mGluR5抗体 程序性细胞死亡受体1 

分 类 号：R742.9[医药卫生—神经病学与精神病学]