B淋巴细胞刺激因子和增殖诱导配体在神经免疫性疾病中的作用  

Role of B lymphocyte stimulator/a proliferation-inducing ligand in neuroimmune diseases

作　　者：丁婕[1] 管阳太[1] Ding Jie;Guan Yangtai(Department of Neurology,Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China)

机构地区：[1]上海交通大学医学院附属仁济医院神经内科,上海200127

出　　处：《中华神经科杂志》2024年第6期661-669,共9页Chinese Journal of Neurology

摘　　要：B淋巴细胞刺激因子(BLyS)和增殖诱导配体(APRIL)是肿瘤坏死因子超家族成员,两者有较强同源性。作为淋巴细胞共刺激因子,能调节多种生物学功能,可调节细胞分化、增殖、存活和效应功能,特别是在调节B细胞和T细胞等免疫功能中发挥重要作用。BLyS/APRIL在视神经脊髓炎谱系疾病、多发性硬化、重症肌无力等神经免疫性疾病的发生发展中起重要作用。本文旨在提升对BLyS/APRIL及其在神经免疫性疾病中作用的认识。B lymphocyte stimulator(BLyS)and a proliferation-inducing ligand(APRIL),both members of the tumor necrosis factor superfamily,share strong homology.As lymphocyte co-stimulators,BLyS/APRIL can regulate a variety of biological functions,including cell differentiation,proliferation,survival,and especially regulate immune functions of B cells and T cells.BLyS/APRIL plays an important role in the occurrence and development of neuroimmune diseases such as neuromyelitis optica spectrum disorders,multiple sclerosis and myasthenia gravis.This paper aims to improve the understanding of BLyS/APRIL and its role in neuroimmune diseases.

关 键 词：B细胞活化因子 增殖诱导配体 神经免疫性疾病 发病机制 视神经脊髓炎谱系疾病 

分 类 号：R741[医药卫生—神经病学与精神病学]