整合素αvβ6在牙体及牙周组织疾病中的研究进展  

Research progress of integrinαvβ6 in dental and periodontal tissue diseases

作　　者：李晓雨 孙维克 高玉光[2] 高艳[2] LI Xiaoyu;SUN Weike;GAO Yuguang;GAO Yan(School of Stomatology,Binzhou Medical University,Shandong,Yantai 264003,China;Department of Children’s Stomatology,Binzhou Medical University Hospital,Shandong,Binzhou 256603,China)

机构地区：[1]滨州医学院口腔医学院,山东烟台264003 [2]滨州医学院附属医院儿童口腔科,山东滨州256603

出　　处：《中国医药科学》2024年第11期29-32,共4页China Medicine And Pharmacy

基　　金：国家自然科学基金项目(81870738)。

摘　　要：人类牙体及牙周组织疾病的发生与发展是一个复杂的过程,涉及细胞-细胞及细胞-基质间的相互作用。整联蛋白是一种在大多数细胞中表达的异二聚体细胞表面受体家族,介导细胞-细胞及细胞-基质间的相互作用,调节细胞的生长、迁移和存活。整合素αvβ6主要在上皮细胞中表达,并在一些炎症、癌症、伤口愈合和纤维化疾病中被诱导,参与调节不同的过程,如细胞增殖、迁移、存活、分化及肿瘤侵袭和转移的各种信号通路。近年来,多项研究表明整合素αvβ6参与牙体组织的发育过程,并且在牙周炎及非牙周炎创伤中发挥关键作用。本文主要论述整合素αvβ6在牙体及牙周组织疾病发生发展中的研究进展,以期提供更好的诊疗思路。The occurrence and development of human dental and periodontal tissue diseases are a complex process,involving the interaction between cells or between cells and matrix.Integrins are a family of heterodimeric cell surface receptors expressed in most cells,which mediates interaction between cells or between cells and matrix and regulates cell growth,migration and survival.Integrinαvβ6 is mainly expressed in epithelial cells,and is induced in some inflammation,cancer,wound healing and fibrosis diseases,and participates in regulating various signal pathways in different processes,such as cell proliferation,migration,survival,differentiation and tumor invasion and metastasis.In recent years,many studies have shown that integrinαvβ6 is involved in the development of dental tissues and plays a key role in periodontitis and nonperiodontitis trauma.The research progress of integrinαvβ6 in the occurrence and development of dental and periodontal diseases is mainly discussed in this paper,so as to provide better diagnosis and treatment ideas.

关 键 词：整合素ΑVΒ6 牙釉质矿化 牙本质 牙周组织 

分 类 号：R780.2[医药卫生—口腔医学]