不同临床病理特征卵巢浆液性肿瘤患者E-cadherin、BRCA1及P53的表达变化研究  

Study on the Expression Change of E-cadherin,BRCA1 and P53 of Patients with Different Clinicopathological Characteristics of Ovarian Serous Tumor

作　　者：陈冬莲 李红红 叶倩倩 CHEN Donglian;LI Honghong;YE Qianqian(Department of Pathology,Ganzhou Women and Children's Health Care Hospital,Ganzhou 341000,China;不详)

机构地区：[1]赣州市妇幼保健院病理科,江西赣州341000

出　　处：《中国医学创新》2024年第18期157-160,共4页Medical Innovation of China

基　　金：江西省卫生健康委科技计划项目(202312059)。

摘　　要：目的:探究不同卵巢浆液性肿瘤中E-钙黏蛋白(E-cadherin)、乳腺癌易感基因1(BRCA1)、P53的表达变化情况。方法:选取2017年12月—2022年2月赣州市妇幼保健院的50例卵巢浆液性癌患者为A组,同时期的40例卵巢交界性浆液性肿瘤患者为B组,30例卵巢良性浆液性囊腺瘤患者为C组。检测及比较三组的组织E-cadherin、BRCA1、P53表达情况,并比较A组中不同年龄、淋巴结转移情况、FIGO分期及不同病理分级者的检测结果。结果:A组的E-cadherin及BRCA1阳性率显著均低于B组及C组,B组则显著均低于C组(P<0.05);A组P53阳性率显著高于B组及C组,B组则显著高于C组(P<0.05)。A组中低级别浆液性癌者E-cadherin和BRCA1阳性率均高于高级别浆液性癌者,低级别浆液性癌者P53阳性率显著低于高级别浆液性癌者,差异均有统计学意义(P<0.05)。A组中不同年龄及FIGO分期者的组织E-cadherin、BRCA1及P53阳性率比较,差异均无统计学意义(P>0.05)。A组有淋巴结转移者E-cadherin和BRCA1阳性率均低于无淋巴结转移者,有淋巴结转移者P53阳性率高于无淋巴结转移者,差异均有统计学意义(P<0.05)。结论:卵巢浆液性癌患者中E-cadherin及BRCA1呈低表达,而P53呈高表达,且不同临床病理情况者存在差异,因此在卵巢浆液性癌的早期筛查检测中有一定的参考价值。Objective:To investigate the expression change of E-cadherin,Breast cancer susceptibility gene 1(BRCA1),and P53 in patients with different clinicopathological characteristics of ovarian serous tumors.Method:A total of 50 patients with ovarian serous carcinoma in Ganzhou Women and Children's Health Care Hospital from December 2017 to February 2022 were selected as group A,40 patients with ovarian borderline serous tumor at the same time were selected as group B,and 30 patients with ovarian benign serous cystadenoma were selected as group C.The expression of tissues E-cadherin,BRCA1,and P53 of three groups of were detected and compared,and the detection results of group A with different age,lymph node metastasis,FIGO stages and different pathological grades were compared.Result:The positive rates of E-cadherin and BRCA1 in group A were significantly lower than those of group B and group C,those in group B were significantly lower than those in group C(P<0.05);the positive rate of P53 in group A was significantly higher than that of group B and group C,that in group B was significantly higher than that in group C(P<0.05).The positive rate of E-cadherin and BRCA1 in low-grade serous cancer patients in group A were higher than those in high-grade serous cancer patients;the positive rate of P53 in low-grade serous cancer patients was significantly lower than that in high-grade serous cancer patients,the differences were statistically significant(P<0.05).There were no statistically significant differences in the positive rates of E-cadherin,BRCA1,and P53 in tissues of patients of different ages and FIGO stages in group A(P>0.05).The positive rates of E-cadherin and BRCA1 in patients with lymph node metastasis in group A were lower than those without lymph node metastasis,and the positive rate of P53 in patients with lymph node metastasis was higher than those without lymph node metastasis,the differences were statistically significant(P<0.05).Conclusion:E-cadherin and BRCA1 are low expression in patients with ovarian se

关 键 词：卵巢浆液性肿瘤 E-钙黏蛋白 乳腺癌易感基因1 P53 临床病理 

分 类 号：R737.31[医药卫生—肿瘤]