雷珠单抗联合玻璃体切割术对DR伴NVG患者手术相关指标及视力恢复的影响  

Effect of Lucentis Combined with Vitrectomy on Surgical Indicators and Visual Recovery in Patients with DR and NVG

作　　者：王佃科 张强 焦婷婷 赵燕 赵黎明 赵文娟 WANG Dianke;ZHANG Qiang;JIAO Tingting;ZHAO Yan;ZHAO Liming;ZHAO Wenjuan(Department of Ophthalmology,Yantai Hospital of Traditional Chinese Medicine,Yantai 264000,Shandong,China)

机构地区：[1]烟台市中医医院眼科,山东烟台264000

出　　处：《糖尿病新世界》2024年第8期26-28,36,共4页Diabetes New World Magazine

摘　　要：目的探究雷珠单抗+玻璃体切割术对糖尿病视网膜病变(Diabetic Retinopathy,DR)伴新生血管性青光眼(Neovascular Glaucoma,NVG)患者手术相关指标及视力恢复的影响。方法回顾性选取2021年9月-2023年8月烟台市中医医院眼科收治的85例DR伴NVG患者的临床资料,按治疗方式的不同分两组,对照组(n=42,共45眼)行玻璃体切割术,观察组(n=43,共47眼)予以雷珠单抗+玻璃体切割术治疗。对比两组手术相关指标、眼压及视力、眼动脉血流动力学指标、并发症发生情况。结果观察组手术时间较对照组短,电凝止血进入眼内的次数较对照组少,差异有统计学意义(P均<0.05)。对比两组术前眼压、视力、眼动脉血流动力学指标,差异无统计学意义(P均>0.05)。与对照组相比,观察组术后3个月眼压、血流阻力系数更低,最佳矫正视力、舒张末期流速、收缩峰值流速均更高,差异有统计学意义(P均<0.05)。观察组并发症总发生率较对照组低,差异有统计学意义(P<0.05)。结论在DR伴NVG患者中予以雷珠单抗、玻璃体切割术联合治疗,能够优化手术相关指标,降低眼压,改善眼动脉血流动力学指标,加快视力恢复,减少并发症。Objective To investigate the effects of Lucentis plus vitrectomy on surgical indicators and visual recovery in patients with diabetic retinopathy(DR)and neovascular glaucoma(NVG).Methods Clinical data of eighty-five pa-tients with DR and NVG treated in the Department of Ophthalmology of Yantai Hospital of Traditional Chinese Medi-cine from September 2021 to August 2023 were retrospectively selected and divided into two groups according to dif-ferent treatment methods.The control group(n=42,total 45 eyes)received vitrectomy for treatment,and the observa-tion group(n=43,total 47 eyes)received Lucentis+vitrectomy for treatment.The relative indexes of operation,intra-ocular pressure and visual acuity,hemodynamic indexes of ocular artery and incidence of complication were compared between the two groups.Results The operation time of the observation group was shorter than that of the control group,and the frequency of electrocoagulation into the eye was less than that of the control group,and the differences were statistically significant(both P<0.05).There were no significant differences in preoperative intraocular pressure,visual acuity and hemodynamics between the two groups(all P>0.05).Compared with the control group,the intraocu-lar pressure and blood flow resistance coefficient of the observation group were lower 3 months after operation,and the optimal corrected visual acuity,end-diastolic flow velocity and peak systolic flow velocity were higher,and the differ-ences were statistically significant(all P<0.05).The total complication rate of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).Conclusion In patients with DR And NVG,the combination of Lucentis and vitrectomy can optimize the operative indicators,reduce the intraocular pressure,improve the hemodynamic indicators of the eye artery,accelerate visual recovery,and reduce complications.

关 键 词：糖尿病视网膜病变 新生血管性青光眼 雷珠单抗 玻璃体切割术 

分 类 号：R77[医药卫生—眼科]