干扰素α-2b联合氯喹那多/普罗雌烯对宫颈上皮内瘤变Leep术后的疗效观察  

Efficacy of interferonα-2b combined with chlorquinaldol-promestriene on cervical intraepithelial neoplasia patients after loop electrosurgical excisional procedure

作　　者：苏燕燕 杨虎 SU Yanyan;YANG Hu(Department of Gynecology,Shunyi District Maternal and Child Health Hospital in Beijing,Beijing 101300,China;Department of Radiology,Hengshui People's Hospital,Hengshui 053000,Hebei Province,China)

机构地区：[1]北京市顺义区妇幼保健院妇科,北京101300 [2]衡水市人民医院放射科,河北衡水053000

出　　处：《中国药师》2024年第6期1041-1047,共7页China Pharmacist

基　　金：首都卫生发展科研专项项目(2022-3-7102)。

摘　　要：目的探究人干扰素α-2b(INFα-2b)联合氯喹那多/普罗雌烯(CP)对宫颈上皮内瘤变(CIN)宫颈环形电切术(LEEP)术后的临床疗效。方法回顾性收集2022年9月至2023年9月北京市顺义区妇幼保健院妇科收治的CIN患者临床资料。根据LEEP术后用药方案不同分为干扰素组(INFα-2b)和联合组(INFα-2b联合CP)。比较治疗前和治疗后3个月炎症因子[C-反应蛋白(CRP)和淀粉样蛋白A(SAA)]和免疫功能因子[CD4^(+)、CD8^(+)和CD4^(+)/CD8^(+)]变化情况。评估治疗后临床疗效[治疗有效率、HPV转阴率和半年复发率]和并发症发生情况。结果共纳入106例CIN患者,其中干扰素组68例,联合组38例。治疗前,两组患者的血清CRP、SAA水平、血液CD4^(+)淋巴细胞比例、CD8^(+)淋巴细胞比例和CD4^(+)/CD8^(+)比值比较差异无统计学意义(P>0.05)。与治疗前相比,治疗后两组患者的血清CRP、SAA水平和血液CD8^(+)淋巴细胞比例显著下降,而血液CD4^(+)淋巴细胞比例和CD4^(+)/CD8^(+)比值显著上升。此外,治疗后联合组血清CRP、SAA水平和血液CD8^(+)淋巴细胞比例显著低于干扰素组(P<0.05),而血液CD4^(+)淋巴细胞比例和CD4^(+)/CD8^(+)比值显著高于干扰素组(P<0.05)。联合组治疗有效率和HR-HPV转阴率显著高于干扰素组(P<0.05)。但两组患者的半年复发率和术后并发症发生率差异无统计学意义(P>0.05)。结论INFα-2b联合CP可改善CIN患者LEEP术后炎症水平和免疫功能、提升临床疗效和HPV转阴率,但不影响半年复发率和并发症发生率。Objective To explore the clinical efficacy of human interferonα-2b(INFα-2b)combined with chlorquinaldol-promestriene(CP)in treating cervical intraepithelial neoplasia(CIN)following a loop electrosurgical excision procedure(LEEP).Methods Clinical data of CIN patients treated at the Shunyi District Maternal and Child Health Hospital in Beijing from September 2022 to September 2023 were retrospectively collected.Patients were divided into two groups based on their postoperative medication regimen:the interferon group(INFα-2b)and the combination group(INFα-2b combined with CP).Changes in inflammatory factors[C-reactive protein(CRP)and serum amyloid A(SAA)]and immune function factors[CD4^(+),CD8^(+),and CD4^(+)/CD8^(+)ratios]were compared before and after 3 months of the treatment.Clinical efficacy[treatment response rate,HPV clearance rate,and six-month recurrence rate]and complications were also assessed.Results A total of 106 CIN patients were included,with 68 in the interferon group and 38 in the combination group.Before treatment,there were no significant differences in serum CRP,SAA levels,blood CD4^(+)lymphocyte ratio,CD8^(+)lymphocyte ratio,and CD4^(+)/CD8^(+)ratio between the two groups(P>0.05).After treatment,both groups showed significant decreases in serum CRP,SAA levels,and blood CD8^(+)lymphocyte ratio(P﹤0.05),and significant increases in blood CD4^(+)lymphocyte ratio and CD4^(+)/CD8^(+)ratio(P﹤0.05),compared with before treatment.In addition,the combination group had significantly lower serum CRP,SAA levels,and blood CD8^(+)lymphocyte ratio,and significantly higher blood CD4^(+)lymphocyte ratio and CD4^(+)/CD8^(+)ratio than the interferon group.The effective rate and HR-HPV clearance rate in the combination group were significantly higher than those in the interferon group.There was no significant difference in the six-month recurrence rate(P﹤0.05)or the postoperative complication rate(P>0.05).Conclusion INFα-2b combined with CP can improve inflammation levels,immune function,clinical efficac

关 键 词：宫颈上皮内瘤变 干扰素Α-2B 氯喹那多/普罗雌烯 宫颈环形电切术 

分 类 号：R737.33[医药卫生—肿瘤]