鸦胆子油乳注射液联合化疗治疗非小细胞肺癌有效性和安全性的系统评价和Meta分析  

A Systematic Review and Meta-analysis of Efficacy and Safety of Brucea Javanica Oil Emulsion Injection Combined with Chemotherapy in the Treatment of Non-small Cell Lung Cancer

作　　者：李鹏涛 刘巧玲 陈士花 薛彩花 迟瑞玲 刘洪训 LI Pengtao;LIU Qiaoling;CHEN Shihua;XUE Caihua;CHI Ruiling;LIU Hongxun(Department of Oncology,Qingdao Huangdao District Central Hospital,Qingdao 266555,China;不详)

机构地区：[1]青岛市黄岛区中心医院肿瘤科,山东青岛266555

出　　处：《中国医学创新》2024年第16期25-31,共7页Medical Innovation of China

基　　金：青岛市医药卫生科研计划项目(2022-WJZD254,2019-WJZD195)。

摘　　要：目的:本文旨在系统评价鸦胆子油乳注射液联合化疗治疗非小细胞肺癌的有效性和安全性。方法:检索PubMed、Embase、中国生物医学文献数据库(CBM)、中国知网(CNKI)、万方等中外数据库建库至2023年3月以来关于鸦胆子油乳注射液联合化疗治疗非小细胞肺癌的文章。本项研究的主要结局是临床收益率(生活质量)、有效率和药物不良反应。采用Cochrane标准进行评价,运用RevMan 5.4软件进行统计分析。结果:纳入16项研究进行Meta分析,共1423例受试者(观察组717例,对照组706例),临床收益率Meta分析结果显示:与对照组比较,观察组患者的临床收益率优于对照组,差异有统计学意义[RR=1.16,95%CI(1.06,1.27),Z=3.15,P=0.002];有效率Meta分析结果显示:观察组有效率高于对照组,差异有统计学意义[RR=1.28,95%CI(1.14,1.43),Z=4.19,P<0.0001];安全性Meta分析结果显示:观察组不良反应发生率低于对照组,差异有统计学意义[RR=0.56,95%CI(0.43,0.73),Z=4.23,P<0.0001]。结论:与单纯应用化疗药物相比,鸦胆子油乳注射液联合化疗其在抗肿瘤有效性和安全性方面有优势,提高临床收益率,降低不良反应,值得临床应用并进一步探讨。Objective:To evaluate the efficacy and safety of Brucea Javanica Oil Emulsion Injection(BJOEI)combined with chemotherapy in the treatment of non-small cell lung cancer(NSCLC).Method:The articles on BJOEI combined with chemotherapy in the treatment of NSCLC were searched from PubMed,Embase,CBM,CNKI,Wanfang and other Chinese and foreign databases from inception to March 2023.The primary out comes of this study were clinical yield(quality of life),effect rate,and adverse drug reactions.Cochrane criteria were used for evaluation,and RevMan 5.4 software was used for statistical analysis.Result:Sixteen studies were included for Meta-analysis,with a total of 1,423 subjects(717 in the observation group and 706 in the control group).Meta-analysis of clinical yield showed that:the clinical return rate of patients in the observation group was better than that in the control group,the difference was makedly significant[RR=1.16,95%CI(1.06,1.27),Z=3.15,P=0.002].The results of Metaanalysis of effective rate showed that the effective rate of the observation group was higher than that of the control group,the difference was statistically significant[RR=1.28,95%CI(1.14,1.43),Z=4.19,P<0.000,1].The results of safety Meta-analysis showed that the incidence of adverse reactions in the observation group was lower than that in the control group,the difference was remarkably significant[RR=0.56,95%CI(0.43,0.73),Z=4.23,P<0.000,1].Conclusion:Compared with chemotherapy drugs alone,BJOEI combined with chemotherapy has advantages in anti-tumor efficacy and safety,improves clinical yield and reduces adverse reactions,and is worthy of clinical application and further discussion.

关 键 词：鸦胆子油乳注射液 化疗 非小细胞肺癌 系统评价 META分析 

分 类 号：R734.2[医药卫生—肿瘤] G353.1[医药卫生—临床医学]