二陈汤合黄芪桂枝五物汤联合rt-PA溶栓治疗急性缺血性脑卒中的临床效果  

Clinical Effect of Erchen Decoction and Huangqi Guizhi Wuwu Decoction and rt-PA Thrombolysis in the Treatment of Acute Ischemic Stroke

作　　者：刘山山 张松松 LIU Shanshan;ZHANG Songsong(Emergency Department,the Second People's Hospital of Dongying,Dongying 257335,China;不详)

机构地区：[1]东营市第二人民医院急诊科,山东东营257335

出　　处：《中国医学创新》2024年第16期111-114,共4页Medical Innovation of China

摘　　要：目的:探讨急性缺血性脑卒中(AIS)患者给予二陈汤合黄芪桂枝五物汤联合重组组织型纤溶酶原激活剂(rt-PA)溶栓治疗的临床效果。方法:选取2022年1月—2024年1月东营市第二人民医院收治的共计120例AIS患者,以随机数字表法分成研究组(60例)与对照组(60例),对照组采用常规西药联合rt-PA溶栓治疗,研究组在对照组基础上给予二陈汤合黄芪桂枝五物汤治疗。比较两组临床效果、认知功能、神经功能、凝血及炎症因子。结果:研究组治疗总有效率(98.33%)较对照组(86.67%)更高(P<0.05)。治疗后,两组简易精神状态评价量表(MMSE)评分均较治疗前升高(P<0.05),美国国立卫生研究院卒中量表(NIHSS)均较治疗前下降(P<0.05),研究组MMSE评分较对照组高(P<0.05),NIHSS评分较对照组低(P<0.05)。治疗后,两组D-二聚体(D-D)、白细胞介素-17(IL-17)、肿瘤坏死因子-α(TNF-α)水平均较治疗前下降(P<0.05),研究组均较对照组低(P<0.05)。结论:AIS患者给予二陈汤合黄芪桂枝五物汤联合rt-PA溶栓治疗,能够提升临床效果,改善患者神经、认知功能,缓解炎症反应。Objective:To explore the clinical effect of Erchen Decoction and Huangqi Guizhi Wuwu Decoction and Recombinant Tissue Plasminogen Activator(rt-PA)thrombolysis in the treatment of patients with acute ischemic stroke(AIS).Method:A total of 120 AIS patients from January 2022 to January 2024 who were admitted in the Second People's Hospital of Dongying were selected,they were divided into the study group(60 cases)and the control group(60 cases)by random number table method.The control group was received conventional western medicine and rt-PA thrombolysis,while the study group was received Erchen Decoction and Huangqi Guizhi Wuwu Decoction on the basis of control group.The clinical efficacy,cognitive function,neurological function,coagulation,and inflammatory factors in both groups were compared.Result:The total effective rate of treatment in the study group(98.33%)was higher than that in the control group(86.67%)(P<0.05).After treatment,the mini-mental state examination(MMSE)scores in both groups were increased compared to those before treatment(P<0.05),the national institutes of health stroke scale(NIHSS)scores were decreased compared to those before treatment(P<0.05),in comparision of the control group,the MMSE scores in the study group were higher(P<0.05),and the NIHSS scores were lower(P<0.05).After treatment,D-dimer(D-D),interleukin-17(IL-17),and tumor necrosis factor-α(TNF-α)levels in both groups were decreased compared to those before treatment(P<0.05);and in comparision of the control group,those in the study group were lower(P<0.05).Conclusion:Treatment of AIS patients with Erchen Decoction and Huangqi Guizhi Wuwu Decoction and rt-PA thrombolysis can improve clinical efficacy,improve neurological and cognitive function,and alleviate inflammatory reactions.

关 键 词：二陈汤合黄芪桂枝五物汤 RT-PA溶栓 缺血性脑卒中 

分 类 号：R743.3[医药卫生—神经病学与精神病学]