非编码RNA通过调控Notch通路影响非小细胞肺癌的生物学行为  

Non-coding RNAs affect the biological behaviors of non-small cell lung cancer by regulating the Notch signaling pathway

作　　者：孙佳珺 董美辰 张树冰[2] 文斗斗[2] SUN Jia-Jun;DONG Mei-Chen;ZHANG Shu-Bing;WEN Dou-Dou(Xiangya School of Medicine,Central South University,Changsha 410013,China;Department of Cell Biology,School of Life Sciences,Central South University,Changsha 410013,China)

机构地区：[1]中南大学湘雅医学院,长沙410013 [2]中南大学生命科学学院细胞生物学系,长沙410013

出　　处：《生命科学》2024年第5期649-657,共9页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(81972312);湖南省卫生健康委科研课题(202102052025)。

摘　　要：Notch信号通路是决定细胞命运的重要通路之一,已被证实在非小细胞肺癌(NSCLC)的增殖、分化和凋亡中起重要作用。在对Notch信号通路与NSCLC的研究中,非编码RNA (ncRNA)对Notch通路的调控是近五年的一个研究热点。其中,微小RNA (miRNA)、长链非编码RNA (lncRNA)和环状RNA (circRNA)通过多种方式调控Notch通路从而影响NSCLC的发生发展。此外,ncRNA对Notch通路的调控还与NSCLC耐药相关。尽管目前ncRNA在NSCLC治疗中的研究较少,但是基于ncRNA的靶向药物将为NSCLC治疗提供新的方案。Notch signaling pathway is one of the important pathways determining cell fate and has been widely studied and confirmed to play pivotal roles in proliferation,differentiation and apoptosis of non-small cell lung cancer(NSCLC).In the study of Notch signaling pathway and NSCLC,the regulation of Notch pathway by non-coding RNAs(ncRNAs)has become a research hotspot in the last five years,among which microRNAs(miRNAs),long chain non-coding RNAs(lncRNAs)and circular RNAs(circRNAs)can affect the progression of NSCLC by regulating the Notch pathway in various ways.In addition,the regulation of Notch pathway by ncRNAs is also associated with drug resistance in NSCLC.Although there are fewer studies on ncRNAs in NSCLC treatment,ncRNA-based targeted drugs will provide new options for NSCLC treatment.

关 键 词：非编码RNA(ncRNA) NOTCH信号通路 非小细胞肺癌(NSCLC) 耐药 

分 类 号：Q522[生物学—生物化学] R734.2[医药卫生—肿瘤]