胃癌微小残留病灶监测的潜在标志物  

Potential markers for surveillance of minimal residual disease in gastric cancer

作　　者：韩永东 郑宜鋆 赵嵩博 张有成[2] HAN Yongdong;ZHENG Yijun;ZHAO Songbo;ZHANG Youcheng(Department of Surgery,Second Clinical Medical College of Lanzhou University,Lanzhou 730030,China;Department of General Surgery,Lanzhou University Second Hospital,Lanzhou 730030,China)

机构地区：[1]兰州大学第二临床医学院,兰州730030 [2]兰州大学第二医院普通外科,兰州730030

出　　处：《生命的化学》2024年第5期761-768,共8页Chemistry of Life

基　　金：甘肃省教育厅产业支撑计划项目(2023CYZC-05);兰州大学第二医院萃英科技创新计划项目(CY2022-MS-B04)。

摘　　要：胃癌是威胁我国居民生命健康的主要恶性肿瘤之一,目前充分的肿瘤切除和辅助药物治疗并未完全阻止疾病复发。微小残留病灶(minimal residual disease,MRD)被认为是导致疾病复发的“源头”之一,治疗后患者MRD水平或状态的动态监测对早期识别肿瘤复发和判断预后具有重要意义。因此,本文综述了有望应用于胃癌领域MRD检测的几种热点分子标志物的相关进展,并探讨其在胃癌MRD长程监测和指导精准治疗方面的应用价值。Gastric cancer is one of the primary malignant tumors threatening the lives and health of residents in China.At present,thorough tumor resection and adjuvant medication have not fully prevented disease recurrence.Minimal residual disease(MRD)is considered one of the“sources”of such recurrences.The dynamic monitoring of MRD level or status post-treatment is of great significance for the early identification of tumor recurrence and prognosis assessment.Therefore,this review summarizes the advancements of several hot molecular markers that can be applied to MRD detection in gastric cancer.It also discusses their value in the long-term monitoring of MRD and in guiding precise treatment for gastric cancer.

关 键 词：胃癌 微小残留病灶 生物标志物 循环肿瘤核酸 外泌体 

分 类 号：R735.2[医药卫生—肿瘤]