运动调节组蛋白去乙酰化改善阿尔茨海默病的研究进展  

Research progress in the improvement of motion-regulated histone deacetylation in Alzheimer's disease

作　　者：汪紫微 梁艳 王运良[1] 沈文清 戚慧 何标 WANG Ziwei;LIANG Yan;WANG Yunliang;SHEN Wenqing;QI Hui;HE Biao(College of Physical Education,Anhui Normal University,Wuhu 241002,China;Anhui Province Student Physical Health Monitoring and Research Center,Anhui Normal University,Wuhu 241002,China)

机构地区：[1]安徽师范大学体育学院,芜湖241002 [2]安徽师范大学安徽省学生体质健康监测与研究中心,芜湖241002

出　　处：《生命的化学》2024年第5期786-794,共9页Chemistry of Life

基　　金：安徽省社会科学创新发展课题项目(2023CX547);安徽省自然科学基金面上项目(2108085MH265)。

摘　　要：阿尔茨海默病(Alzheimer’s disease,AD)是以渐进性认知功能障碍和记忆损害为主要特征的神经退行性疾病,是一种严重威胁老年人身心健康的中枢神经系统疾病。AD发病机制复杂,已有的研究发现,组蛋白去乙酰化参与调节AD的病理进程。运动作为一种行之有效的非药物干预手段对预防和延缓AD的发生具有重要作用。为此,本文综述了组蛋白去乙酰化在AD发病中的作用及其在运动缓解AD中的作用机制。Alzheimer's disease(AD)is a neurodegenerative disease characterized by progressive cognitive dysfunction and memory impairment.It is a central nervous system disease that seriously threatens the physical and mental health of old age.The pathogenesis of AD is complex.Previous studies have found that histone deacetylation is involved in regulating the pathological process of AD.As an effective non-drug intervention,exercise plays an important role in preventing and delaying the occurrence of AD.This paper reviewed the role of histone deacetylation in the pathogenesis of AD and the mechanism of action in the alleviation of AD by exercise.

关 键 词：阿尔茨海默病 运动 组蛋白去乙酰化酶 组蛋白去乙酰化 

分 类 号：R749.16[医药卫生—神经病学与精神病学]