岩藻聚糖硫酸酯在心血管疾病中的应用  

The application of fucoidan sulfate in cardiovascular diseases

作　　者：刘长杰 王言 宋淑亮 LIU Changjie;WANG Yan;SONG Shuliang(Department of Pharmacy,Affliated Hospital of Shandong Second Medical University,Weifang 261035,China;Marine College,Shandong University,Weihai 264209,China)

机构地区：[1]山东第二医科大学附属医院药学部,潍坊261035 [2]山东大学(威海)海洋学院,威海264209

出　　处：《生命的化学》2024年第5期811-819,共9页Chemistry of Life

基　　金：山东省自然科学基金面上项目(ZR2022MH279);山东省科技创新能力提升工程项目(2023TSGC0658)。

摘　　要：岩藻聚糖硫酸酯(fucoidan)是一种带负电荷的大分子水溶性硫酸化多糖,存在于褐藻和一些海洋无脊椎动物中。岩藻聚糖硫酸酯具有多种生物学功能,包括抗肿瘤、降血脂、抗炎抗氧化、抗血栓、抗病毒等,在心血管疾病的治疗方面具有广泛的应用前景。本文主要对岩藻聚糖硫酸酯在降血脂、抗血栓、降血压、抗动脉粥样硬化方面的作用进行了总结,以期为将岩藻聚糖硫酸酯开发为治疗心血管疾病的新型药物提供参考。Fucoidan is a negatively charged macromolecular water-soluble sulfated polysaccharide that exists in brown algae and some marine invertebrates.It has a variety of biological functions,including anti-tumor,hypolipidemic,anti-inflammatory and antioxidant,anti-thrombus,anti-virus and so on.It has a wide application prospect in the treatment of cardiovascular diseases.The role of fucoidan in lowering blood lipid,antithrombotic,lowering blood pressure,and anti-atherosclerosis was summarized to provide a reference for the development of fucoidan as a new drug for cardiovascular disease.

关 键 词：岩藻聚糖硫酸酯 降血脂 抗血栓 降血压 抗动脉粥样硬化 

分 类 号：R54[医药卫生—心血管疾病]