首发精神分裂症患者血清泌乳素水平与言语性幻听、认知功能受损的相关性研究  

Study on the correlation between serum prolactin level and speech auditory hallucinations and cognitive impairment in first-episode schizophrenia

作　　者：任静 李迎晨 梁曼丽 陈长浩 REN Jing;LI Yingchen;LIANG Manli;CHEN Changhao(Department of Psychiatry,Second People's Hospital of Suzhou City,Suzhou,Anhui 234000,China)

机构地区：[1]宿州市第二人民医院精神科,安徽宿州234000

出　　处：《中国实验诊断学》2024年第6期654-658,共5页Chinese Journal of Laboratory Diagnosis

基　　金：2020年度安徽省自然科学基金项目(编号:2008085QH407)。

摘　　要：目的探讨首发精神分裂症(FES)患者血清泌乳素(PRL)水平与言语性幻听、认知功能受损的关系。方法选取2021年1月至2023年12月期间宿州市第二人民医院收治的123例未治疗的FES患者,根据PRL检测水平分为正常PRL组(n=72),和高PRL组(n=51)。比较不同性别正常PRL组与高PRL组一般资料、阳性与阴性症状量表(PANSS)症状、言语性幻听[中文版精神症状评定量表-幻听分量表(PSYRATS-AH)]及认知功能[认知功能蒙特利尔认知评估量表(MoCA)],采用Pearson相关性分析未治疗FES患者PSYRATS-AH总分、MoCA总分与血清PRL水平的关系。结果高PRL组甘油三酯(TG)水平高于正常PRL组(P<0.05)。与正常PRL组相比,高PRL组阳性症状、阴性症状、一般精神病理及PANSS总分较高(P<0.05);与正常PRL组男性相比,高PRL组男性阴性症状评分较高(P<0.05)。与正常PRL组相比,高PRL组PSYRATS-AH总分较高,MoCA总分较低(P<0.05);与正常PRL组男性相比,高PRL组男性MoCA总分较低(P<0.05),而与正常PRL组女性相比,高PRL组女性PSYRATS-AH总分较高(P<0.05)。多因素Logistic回归模型分析结果显示,PSYRATS-AH总分、MoCA总分是影响血清PRL升高的独立危险因素(P<0.05)。Pearson相关性分析显示,男性FES患者血清PRL与MoCA总分成负相关(r=-0.532,P<0.001),女性FES患者血清PRL与PSYRATS-AH总分成正相关(r=0.501,P<0.001)。结论未治疗FES患者体内血清PRL异常高表达,与言语性幻听及认知功能受损关系密切。Objective To investigate the relationship between serum prolactin(PRL) level, auditory hallucinations and cognitive impairment in patients with first-episode schizophrenia(FES).Methods 123 untreated FES patients admitted to Department of psychiatry, second people's hospital of suzhou city hospital from January 2021 to December 2023 were selected and divided into normal PRL group(n=72) and high PRL group(n=51) according to the level of PRL detection.General data, Positive and negative Symptom Scale(PANSS) symptoms, verbal auditory hallucinations [PSYRATS-AH]and cognitive function [Montreal Cognitive Assessment Scale of Cognitive Function(MoCA)] were compared between normal and high PRL groups of different genders.Pearson correlation was used to analyze the relationship between PSYRATS-AH total score, MoCA total score and serum PRL level in untreated FES patients.Results The level of triglyceride(TG) in high PRL group was higher than that in normal PRL group(P<0.05).Compared with normal PRL group, positive symptoms, negative symptoms, general psychopathology and total score of PANSS in high PRL group were higher(P<0.05).Compared with the normal PRL group, the men with high PRL had higher negative symptom scores(P<0.05).Compared with normal PRL group, the total score of PSYRATS-AH was higher and the total score of MoCA was lower in high PRL group(P<0.05).Compared with the normal PRL group, the total score of MoCA in the high PRL group was lower(P<0.05),and the total score of PSYRATS-AH in the high PRL group was higher than that in the normal PRL group(P<0.05).Multivariate Logistic regression model showed that the total score of PSYRATS-AH and the total score of MoCA were independent risk factors for the increase of serum PRL(P<0.05).Pearson correlation analysis showed that serum PRL in male patients with FES was negatively correlated with MoCA(r=-0.532,P<0.001),and serum PRL in female patients with FES was positively correlated with PSYRATS-AH(r=0.501,P<0.001).Conclusion Abnormal high expression of serum PRL in untr

关 键 词：首发精神分裂症 泌乳素 言语性幻听 认知功能受损 

分 类 号：R749.3[医药卫生—神经病学与精神病学]