ROR2 promotes invasion and chemoresistance of triple-negative breast cancer cells by activating PI3K/AKT/mTOR signaling  

作　　者：XIA DA HAN GE JUNFENG SHI CHUNHUA ZHU GUOZHU WANG YUAN FANG JIN XU 

机构地区：[1]Department of Breast and Thyroid,Nanjing First Hospital,Nanjing Medical University,Nanjing,China [2]Department of General Surgery,The First Affiliated Hospital of Nanjing Medical University,Nanjing,China [3]Department of Oncology,Nanjing First Hospital,Nanjing Medical University,Nanjing,China [4]Department of Pathology,Nanjing First Hospital,Nanjing Medical University,Nanjing,China

出　　处：《Oncology Research》2024年第7期1209-1219,共11页肿瘤学研究（英文）

基　　金：supported by Medical and Health Research Project of Nanjing Health Science and Technology Development Special Fund(ZKX21040).

摘　　要：Objective:This study aimed to investigate the role of receptor tyrosine kinase-like orphan receptor 2(ROR2)in triple-negative breast cancer(TNBC).Methods:ROR2 expression in primary TNBC and metastatic TNBC tissues was analyzed by immunohistochemical staining and PCR.ROR2 expression in TNBC cell lines was detected by PCR and Western blot analysis.The migration,invasion and chemosensitivity of TNBC cells with overexpression or knockdown of ROR2 were examined.Results:ROR2 expression was high in metastatic TNBC tissues.ROR2 knockdown suppressed the migration,invasion and chemoresistance of TNBC cells.ROR2 overexpression in MDA-MB-435 cells promoted the migration,invasion,and chemoresistance.Moreover,ROR2 knockdown in HC1599 and MDA-MB-435 adriamycin-resistant cells enhanced chemosensitivity to adriamycin.ROR2 could activate PI3K/AKT/mTOR signaling in TNBC cells.Conclusion:ROR2 is upregulated and promotes metastatic phenotypes of TNBC by activating PI3K/AKT/mTOR signaling.

关 键 词：Receptor tyrosine kinase-like orphan receptor 2 Triplet-negative breast cancer Proliferation Apoptosis PI3K/AKT/mTOR signaling Metastasis 

分 类 号：R737.9[医药卫生—肿瘤]