强α_(1)受体拮抗的非典型抗精神病药物导致精神分裂症患者自感发热不适1例  

Atypical antipsychotic drugs with strong alpha 1 receptor antagonism resulting in self-perceived hot in patients with schizophrenia:a case report

作　　者：孙林远 高阳 苏斌 李名立[1] Sun Linyuan;Gao Yang#;Su Bin;Li Mingli(West China Hospital,Sichuan University,Chengdu 610041,China;Karamay Hospital of Integrated Traditional Chinese and Western Medicine,Karamay 834000,China)

机构地区：[1]四川大学华西医院,四川成都610041 [2]克拉玛依市中西医结合医院,新疆克拉玛依834000

出　　处：《四川精神卫生》2024年第3期267-269,共3页Sichuan Mental Health

摘　　要：本文报道了1例精神分裂症患者服用强α_(1)受体拮抗的非典型抗精神病药物奥氮平、利培酮、帕利哌酮和氯氮平后出现自感身体发热不适,考虑系药物副反应,换用阿立哌唑后,患者自感发热不适消失。该病例报道旨在提示精神科医生关注强α_(1)受体拮抗的非典型抗精神病药物导致的副反应,并需结合药物作用机制、患者的病理生理、个体差异等综合考虑,提高患者的治疗依从性,改善预后。This article reported a case of a patient with schizophrenia who experienced self-perceived fever and discomfort after taking atypical antipsychotic drugs with strong alpha 1 receptor antagonism,which included olanzapine,risperidone,paliperidone and clozapine.Such phenomenon was believed to be a medication side effect.Therefore,the patient switched to aripiprazole and the fever disappeared.This case report is intended to remind psychiatrists to pay attention to the side effects caused by atypical antipsychotic drugs with strong alpha 1 receptor antagonism as well as to suggest that various factors should be considered,including mechanisms of drug action,patient pathophysiology and individual differences,in order to improve treatment compliance and prognosis.

关 键 词：精神分裂症 强α_(1)受体拮抗的非典型抗精神病药物 发热 

分 类 号：R749.3[医药卫生—神经病学与精神病学]