肠脂肪酸结合蛋白在肠黏膜屏障损伤相关疾病中的作用研究进展  

Research progress on the role of intestinal fatty acid binding proteins in diseases associated with intestinal mucosal barrier damage

作　　者：苏小优 万燕 陈超超 蓝程[1] SU Xiaoyou;WAN Yan;CHEN Chaochao;LAN Cheng(Department of Gastroenterology,Hainan General Hospital,Hainan Affiliated Hospital of Hainan Medical University,Haikou 570311,China)

机构地区：[1]海南省人民医院海南医学院附属海南医院消化内科,海南海口570311

出　　处：《海南医学院学报》2024年第12期939-946,共8页Journal of Hainan Medical University

基　　金：国家自然科学基金(82060102);海南省自然科学基金(821RC1116)。

摘　　要：肠道是人体持续暴露于外部环境的最大器官之一,发挥着重要的物理及化学屏障作用保护人体免受致病菌侵害,肠黏膜屏障作为肠道的重要组成部分,其完整性对维持肠道微生态平衡起关键作用,肠黏膜屏障破坏可导致肠道菌群失调及易位,与多种疾病的发生发展相关。肠脂肪酸结合蛋白(intestinal fatty acid binding protein,I‑FABP)是脂肪酸结合蛋白家族中的一种,对肠道损伤具有特异性,在肠道发生损伤、缺血、肠黏膜屏障损伤及通透性增加时会迅速释放入血液循环,I‑FABP水平升高是反映肠道损伤的重要标志物,临床上很多疾病常合并肠道功能障碍,本文主要对I‑FABP的结构特征、功能及其与肠黏膜屏障相关疾病的关系进行综述。Intestinal tract is one of the largest organs in human body that is continuously exposed to the external environment,and it plays an important role as a physical and chemical barrier to protect the human body from pathogens.As an important part of the intestinal tract,the integrity of the intestinal mucosal barrier plays a key role in maintaining the intestinal microecological bal-ance.The destruction of the intestinal mucosal barrier can lead to the imbalance and translocation of intestinal flora,which is relat-ed to the occurrence and development of various diseases.Intestinal fatty acid binding protein(I-FABP)is one of the fatty acidbinding protein family,which exhibits specificity towards intestinal injury and will be released into the blood circulation rapidly when intestinal injury,ischemia,intestinal mucosal barrier damage and permeability increase occur.The elevated level of I-FABP is an important marker of intestinal injury,and intestinal dysfunction is often associated with many clinical diseases.This article mainly reviews the structural characteristics and function of I-FABP and its relationship with intestinal mucosal barrier related diseases.

关 键 词：肠脂肪酸结合蛋白 结构特征 功能 肠黏膜屏障 肠道损伤 

分 类 号：R574[医药卫生—消化系统]