不同类型他汀在皮层脑梗死后癫痫中的价值比较  

Comparison of the Value of Different Types of Statins in Epilepsy after Cortical Cerebral Infarction

作　　者：何敏[1,2] 张小伟 吴涛涛 韩小建 屈新辉 蒋玲霞[1,2] HE Min;ZHANG Xiao-wei;WU Tao-tao;HAN Xiao-jian;QU Xin-hui;JIANG Ling-xia(Jiangxi Provincial People's Hospital,Nanchang 330006;First Affiliated Hospital of Nanchang Medical College,Jiangxi,Nanchang 330006)

机构地区：[1]江西省人民医院,南昌330006 [2]南昌医学院第一附属医院,江西南昌330006

出　　处：《实用中西医结合临床》2024年第9期9-12,16,共5页Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine

基　　金：江西省卫生健康委员会科技计划项目(编号:202130060)。

摘　　要：目的 比较不同类型他汀降低皮层脑梗死后癫痫的价值。方法 选取2016年1月至2022年9月在江西省人民医院神经内科就诊,首次发生急性皮层脑梗死,既往无癫痫病史者,共纳入800例。将未接受他汀治疗者纳入空白组,共200例。其余患者随机接受阿托伐他汀、瑞舒伐他汀、辛伐他汀治疗,分别纳入阿托伐他汀组、瑞舒伐他汀组、辛伐他汀组,各200例。比较各组卒中后癫痫发生率、早期痫样发作发生率、脑梗死的复发率,监测他汀治疗组肝肾功能、肌酶水平。结果 空白组脑梗死后癫痫发生率明显高于阿托伐他汀组、瑞舒伐他汀组及辛伐他汀组,差异有统计学意义(P<0.05)。空白组早期痫样发作的发生率最高,而阿托伐他汀组早期痫样发作的发生率最低,晚期痫样发作发生率最高,四组早期、晚期痫样发作率两两比较,差异有统计学意义(P<0.05)。空白组脑梗死的复发率最高,其次为辛伐他汀组,而阿托伐他汀组脑梗死的复发率最低,四组中脑梗死的复发率两两比较,差异有统计学意义(P<0.05)。阿托伐他汀组、瑞舒伐他汀组、辛伐他汀组均发生肝肾功能、肌酶明显异常等不良反应,但两两比较,差异无统计学意义(P>0.05)。结论 他汀可降低皮层脑梗死后癫痫、早期痫样发作的发生,阿托伐他汀在降低卒中后癫痫、早期痫样发作的发生率,降低脑梗死的复发率方面优于瑞舒伐他汀和辛伐他汀,且不增加肝肾功能损害及肌酶升高的副作用。Objective To compare the value of different types of statins in reducing epilepsy after cortical cerebral infarction,MethodsA total of 800 patients who experienced acute cortical cerebral infarction for the first time and had no history of epilepsy from January 2016 to September 2022 at the Neurology Department of Jiangxi Provincial People's Hospital were selected.200 Individuals who did not receive statin treatment were included in the blank group.The remaining patients were randomly treated with atorvastatin,rosuvastatin,and simvastatin,with 200 patients in each of the atorvastatin group,rosuvastatin group,and simvastatin group.Compared the incidence of post-stroke epilepsy,early epileptic seizures,and recurrence of cerebral infarction among different groups,and monitor liver and kidney function and muscle enzyme levels in the statin treatment group.Results The incidence of epilepsy after cerebral infarction in the blank group was significantly higher than that in the atorvastatin group,rosuvastatin group,and simvastatin group,and the difference was statistically significant(P<0.05).The blank group had the highest incidence of early seizure,while the atorvastatin group had the lowest incidence of early seizure and the highest incidence of late seizure.The early and late seizure rates of the four groups were compared pairwise,and the difference was statistically significant(P<0.05).The blank group had the highest recurrence rate of cerebral infarction,followed by the simvastatin group,while the atorvastatin group had the lowest recurrence rate of cerebral infarction.The recurrence rate of cerebral infarction was compared pairwise among the four groups,and the difference was statistically significant(P<0.05).The atorvastatin group,rosuvastatin group,and simvastatin group all experienced adverse reactions such as significant abnormalities in liver and kidney function and muscle enzymes,but there was no statistically significant difference between the two groups(P>0.05).Conclusion Statin can reduce the incidence of

关 键 词：卒中后癫痫 皮层脑梗死 不同类型他汀 

分 类 号：R742.1[医药卫生—神经病学与精神病学]