2018—2022年四川地区归因于HPV感染的恶性肿瘤发病及死亡情况变化分析  

Analyses of changes in the incidence and mortality of malignant tumors attributed to HPV infection,Sichuan,2018-2022

作　　者：叶波[1] 李玉苹 张开炯 王东生 叶斌[2] YE Bo;LI Yu-ping;ZHANG Kai-jiong;WANG Dong-sheng;YE Bin(Laboratory Department,Sichuan Cancer Hospital,Chengdu,Sichuan 610041,China;不详)

机构地区：[1]四川省肿瘤医院检验科,四川成都610041 [2]成都市第一人民医院呼吸科

出　　处：《现代预防医学》2024年第12期2300-2304,共5页Modern Preventive Medicine

摘　　要：目的分析2018—2022年四川地区归因于人乳头瘤病毒(human papillomavirus,HPV)感染的恶性肿瘤发病及死亡情况。方法收集2018年1月—2022年12月四川地区人口数、肿瘤发病率、死亡率,分年龄、性别计算各恶性肿瘤发病、死亡归因于HPV感染的人群归因分值(Population Attributable Fraction,PAF)。结果2018—2022年四川地区居民HPV感染对常见恶性肿瘤发病和死亡的人口归因比例分别为65.0%和59.2%。男性口咽、口腔及喉恶性肿瘤发病归因HPV(PAF)均高于女性(χ^(2)值=78.904,P<0.001);城市人群宫颈、外阴、口腔及喉恶性肿瘤发病归因HPV(PAF)均高于农村人群(χ^(2)值=119.03,P<0.001);此外,归因于HPV感染的肿瘤发病与年龄的关系存在性别差异(P<0.05),即男性各个肿瘤发病年龄更为提前。男性口咽、口腔及喉恶性肿瘤死亡归因HPV(PAF)均高于女性(χ^(2)值=110.578,P<0.001);城市人群宫颈、肛门、口咽、口腔及喉恶性肿瘤死亡归因HPV(PAF)均高于农村人群(χ^(2)值=66.285,P<0.001);此外,归因于HPV感染的肿瘤死亡与年龄的关系存在性别差异(P<0.05),即男性口腔、口咽恶性肿瘤死亡年龄更为提前,而女性肛门恶性肿瘤死亡年龄更为提前。结论2018—2022年四川地区归因于HPV感染的肿瘤发病、死亡人数较多,且发病、死亡呈现增高趋势,及时筛查宫颈癌是降低归因于HPV肿瘤发病、死亡率的关键。Objective To analyze the incidence and mortality of malignant tumors attributed to HPV infection in Sichuan region from 2018 to 2022.Methods From January 2018 to December 2022,the population,tumor incidence rate and mortality in Sichuan were collected,and the population attributable fraction(PAF)attributable to HPV infection was calculated by age and sex.Results The population attributable proportions of HPV infection among residents in Sichuan region from 2018 to 2022 for the incidence and mortality of common malignant tumors were 65.0%and 59.2%respectively.The attribution of HPV(PAF)to the incidence of malignant tumors in the oropharynx,oral cavity,and throat of males was higher than that of females(χ^(2)=78.904,P<0.001).The attributable HPV(PAF)of cervical,vulva,oral,and laryngeal malignant tumors in urban populations was higher than that in rural populations(χ^(2)=119.03,P<0.001).In addition,there was a gender difference(P<0.05)in the relationship between the incidence of tumors attributed to HPV infection and age,indicating that males had earlier onset ages for various tumors.The attribution of HPV(PAF)to death in male oropharyngeal,oral,and laryngeal malignant tumors was higher than that in females(χ^(2)=110.578,P<0.001).The mortality attributable HPV(PAF)of cervical,anal,oropharyngeal,oral,and laryngeal malignant tumors in urban populations was higher than that in rural populations(χ^(2)=66.285,P<0.001).In addition,there was a gender difference(P<0.05)in the relationship between tumor mortality attributed to HPV infection and age,with males dying earlier for oral and oropharyngeal malignancies,and females dying earlier for anal malignancies.Conclusion From 2018 to 2022,the incidence and death of tumors attributed to HPV infection in Sichuan region are more,and the incidence and death show an increasing trend,among which timely screening of cervical cancer is the key to reduce the incidence and death of HPV tumors.

关 键 词：人乳头瘤病毒 恶性肿瘤 人群归因分值 发病 死亡 

分 类 号：R73[医药卫生—肿瘤]