科教融合综合性创新实验设计:功能型枝化多肽光疗体系的制备与性能研究  

Comprehensive Innovative Experiment Design Based on Integration of Science and Education:Preparation and Properties of Functional Dendritic Peptide Phototherapy System

作　　者：陈思[1] 周雨田 马晓雨 王文嵩 刘凡[1] 鄢国平[1,2] 樊锦轩 CHEN Si;ZHOU Yu-Tian;MA Xiao-Yu;WANG Wen-Song;LIU Fan;YAN Guo-Ping;FAN Jin-Xuan(School of Material Science and Engineering,Wuhan Institute of Technology,Wuhan 430205,China;College of Chemical and Material Engineering,Quzhou University,Quzhou 324000,China;College of Life Science and Technology,Huazhong University of Science and Technology,Wuhan 430074,China)

机构地区：[1]武汉工程大学材料科学与工程学院,湖北武汉430205 [2]衢州学院化学与材料工程学院,浙江衢州324000 [3]华中科技大学生命科学与技术学院,湖北武汉430074

出　　处：《化学教育（中英文）》2024年第12期82-89,共8页Chinese Journal of Chemical Education

基　　金：教育部产学合作协同育人项目:220606537020143(复合型人才培养背景下思政引领、科教融合的“有机化学”课程建设新探索);武汉工程大学2020年教学研究项目——“E+”国家人才培养模式创新实验区专项:X202075(“英语+材料化学”复合型国际化人才培养模式效果实证研究);武汉工程大学课程思政示范课程“有机化学(上)”。

摘　　要：根据课程特点,设计了综合性创新实验“功能型枝化多肽光疗体系的制备与性能研究”,该实验以解决光敏剂IR780水溶性差、体内稳定性不佳及细胞摄取效率偏低等缺陷为目的,利用亲疏水作用将光敏剂IR780包载在两亲性功能枝化多肽疏水空腔内构建光疗体系RI。通过一系列检测手段对光疗体系RI的性能进行了表征,并在实验具体实施过程中强化了学生的实验技能,培养了学生的科研素养。Based on the charactristics of the course,a comprehensive innovative experiment,preparation and properities of functional dendritic peptide phototherapy system,was desinged.The experiment aims to solve the defects such as limited water solubility,poor stability,rapid metabolism and indiscriminate toxicity of photosensitizer IR780.The phototherapy system RI was constructed by encapsulating photosensitizer IR780 in the hydrophobic cavity of amphiphilic functional branched peptide by hydrophilic and hydrophobic effect.The performance of phototherapy system RI was characterized by electrospray ionization mass spectrometry,nuclear magnetic resonance spectroscopy,ultraviolet-visible spectrophotometer,particle size and Zeta potentiometer,transmission electron microscopy,photothermal imager and cell experiments,and the experimental skills of students were strengthened in the specific implementation process of the experiment.

关 键 词：功能型多肽 光热转换效率 科教融合 综合性创新实验 

分 类 号：O629.72-4[理学—有机化学] G642[理学—化学]