巨噬细胞极化与口腔疾病关系的研究进展  

Research progress in relationship between macrophage polarization and oral diseases

作　　者：于依岩 张志民[1] 陈佳文 刘新 李岩 赵洪岩[1] YU Yiyan;ZHANG Zhimin;CHEN Jiawen;LIU Xin;LI Yan;ZHAO Hongyan(Department of Dentistry and Endodontics,Stomatology Hospitial,Jinlin University,Changchun 130021,China)

机构地区：[1]吉林大学口腔医院牙体牙髓科,吉林长春130021

出　　处：《吉林大学学报（医学版）》2024年第3期864-871,共8页Journal of Jilin University：Medicine Edition

基　　金：吉林省卫健委科技能力提升计划项目(2021TC028)。

摘　　要：巨噬细胞作为机体免疫系统的重要组成部分,可以在不同环境中被不同细胞分子诱导极化为M1和M2型巨噬细胞,参与各种疾病的进展。在炎症反应中,M1型巨噬细胞主要作为促炎细胞,促进炎症进展、组织破坏和骨吸收;M2型巨噬细胞作为抑炎细胞参与组织的愈合和骨修复。在肿瘤微环境中,M1和M2型巨噬细胞的作用则相反。牙周炎和牙髓炎等炎症反应及口腔鳞状细胞癌(OSCC)是口腔中最常见的炎症和肿瘤。因此,现就国内外相关研究,对巨噬细胞在牙周炎、种植体周围炎和牙髓炎等口腔炎症反应,正畸过程中的骨改建和OSCC中的极化进行总结,阐述巨噬细胞在炎症、肿瘤和骨改建过程中的代谢活动及巨噬细胞极化调控疾病发生发展的机制,为临床治疗提供新思路。The macrophages,as a crucial component of the body's immune system,can be polarized into M1 and M2 types by different cellular molecules in various environments,and contribute to the progression of various diseases.In inflammatory responses,the M1 macrophages are primarily regarded as the pro-inflammatory cells,facilitate the inflammation progression,tissue destruction,and bone resorption,while M2 macrophages,as inflammatory cells,participate in tissue healing and bone repairment.In the tumor microenvironment,the roles of M1 and M2 macrophages are reversed.The periodontitis,pulpitis,and oral squamous cell carcinoma(OSCC) are the most prevalent inflammation and tumor in the oral cavity.Therefore,this article summarizes the relevant researches from home and abroad on the polarization of macrophages in oral inflammatory responses such as periodontitis,peri-implantitis,and pulpitis,bone remodeling during orthodontic treatment,and OSCC,and elucidate the metabolic activities of macrophages in infiammation,tumor,and bone remodeling and the mechanism of regulating the onset and development of diseases by the macrophage polarization,and provides new perspectives for the clinical treatment.

关 键 词：巨噬细胞极化 炎症 口腔鳞状细胞癌 骨改建 牙周炎 

分 类 号：R78[医药卫生—口腔医学]