微小RNAs在外周神经损伤修复中作用的研究进展  

Research progress of the role of miRNAs in peripheral nerve repair

作　　者：王家彦 朱明媚 汤欣 Wang Jiayan;Zhu Mingmei;Tang Xin(Key Laboratory of Neuroregeneration,Co-innovation Center of Neuroregeneration,Nantong University,Nantong 226001,Jiangsu,China)

机构地区：[1]南通大学神经再生重点实验室神经再生协同创新中心,江苏南通226001

出　　处：《中国医学前沿杂志（电子版）》2024年第6期58-64,共7页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

基　　金：国家自然科学基金(82272167)。

摘　　要：微小RNAs(microRNAs,miRNAs)是一类长度约为22个核苷酸的非编码RNAs,在神经发育、再生和疾病中起着至关重要的作用。周围神经损伤后,许多miRNAs会发生差异表达,这些差异表达的miRNAs通过负向调控下游靶基因的表达,参与受损神经的修复与再生。本文就miRNAs在周围神经再生中的调控作用进行综述,为周围神经损伤后的治疗提供潜在的策略。microRNAs(miRNAs)are a class of non-coding RNAs about 22 nucleotides in length that play a vital role in neural development,regeneration and disease.After peripheral nerve injury,many miRNAs are differentially expressed,and these differentially expressed miRNAs participate in neural repair and regeneration by negatively regulating the expression of downstream target genes.In this review,the role of miRNAs in peripheral nerve regeneration will be summarized,and potential strategies will be provided for the treatment of peripheral nerve injury.

关 键 词：周围神经损伤 微小RNA 施万细胞 DRG神经元 巨噬细胞 

分 类 号：R745[医药卫生—神经病学与精神病学]