基于小肠细菌过度增殖的肠道微生物失调与帕金森病的相关性  

Correlation between gut microbiota dysregulation and Parkinson’s disease based on small intestinal bacterial overgrowth

作　　者：周倩 杨兴隆 ZHOU Qian;YANG Xinglong(The First Affiliated Hospital of Kunming Medical University,Kunming 650032,China)

机构地区：[1]昆明医科大学第一附属医院,云南昆明650032

出　　处：《中国实用神经疾病杂志》2024年第7期906-910,共5页Chinese Journal of Practical Nervous Diseases

基　　金：国家自然科学基金地区基金项目(编号:81960242)。

摘　　要：越来越多的证据表明微生物和大脑通过所谓的肠-脑轴紧密相连。帕金森病(PD)是一种常见的神经退行性蛋白质疾病,目前尚无对其发生、发展有效的干预措施。肠道微生物群失调及其代谢产物在PD的发生及进展中可能起一定作用,因此也是治疗PD的潜在方式。小肠细菌过度增殖(SIBO)在PD中有较高发病率,并可能与胃肠道症状(如腹胀、嗳气、腹痛等)和运动症状波动有关。考虑到SIBO对PD发生及进展的潜在机制,SIBO的根除和小肠微生物群的其他调节/操作可能会减缓PD进展。因此,本文主要对肠道微生物群失调及其代谢产物与PD相关性的研究进展,尤其SIBO在PD中的应用进行阐述,进一步认识两者之间的联系,以期延迟或阻止PD发生、发展,对PD治疗提供新思路。There is growing evidence that microbiota and the brain are closely linked through the gut-brain axis.Parkinson’s disease(PD)is a common neurodegenerative protein disorder for which no disease interventions are available.Gut microbiota dysbiosis and its metabolites may play a role in the onset and progression of PD,so it is also a potential way to treat PD.Small intestinal bacterial overgrowth(SIBO)has a high prevalence in PD and may be associated with gastrointestinal symptoms(e.g.bloating,belching,abdominal pain,etc.)and fluctuations in motor symptoms.Considering the potential mechanisms of SIBO on PD onset,progression,eradication of SIBO,and other modulation/manipulation of the small intestinal microbiota may slow down PD progression.Therefore,this review focuses on the progress of research on gut microbiota dysbiosis and its metabolites and PD,which is the application of SIBO in PD,to further understand the link between the two,delay or stop the onset and progression of PD,and provide new ideas for treatment.

关 键 词：肠-脑轴 肠道微生物群 Α-突触核蛋白 帕金森病 小肠细菌过度增殖 

分 类 号：R742.5[医药卫生—神经病学与精神病学]