结直肠癌患者全身免疫炎症指数的影响因素分析及其对患者术后复发率的影响  

Analysis of influencing factors of systemic immune inflammatory index in patients with colorectal cancer and its influence on postoperative recurrence rate

作　　者：张蕊 郭胜男 ZHANG Rui;GUO Shengnan(Oncology Department,Taikang Xian People's Hospital,Zhoukou 461400;No.5 Oncology Department,Anyang Tumor Hospital,Anyang 455000,China)

机构地区：[1]太康县人民医院肿瘤内科,河南周口461400 [2]安阳市肿瘤医院肿瘤内五科,河南安阳455000

出　　处：《临床医学研究与实践》2024年第19期37-40,共4页Clinical Research and Practice

摘　　要：目的探究全身免疫炎症指数(SII)在结直肠癌患者中的临床意义。方法回顾性分析2019年1月至2021年1月收治的122例结直肠癌患者,所有患者手术前均计算SII,根据SII结果将其分为高SII组(n=57)和低SII组(n=65)。采用多因素Logistic回归分析探讨影响结直肠癌患者SII的因素;所有患者均接受为期2年的随访,记录并比较高SII组和低SII组术后6个月及术后1、1.5、2年的存活情况、肿瘤复发率。结果两组的Karnofsky功能状态(KPS)评分、糖类抗原125(CA125)水平、肿瘤直径、术前白蛋白(Alb)水平及病理学TNM分期比较,差异具有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,肿瘤直径>5 cm、术前Alb≤35.00 g/L及病理学TNM分期T_(3)~T_(4)期是结直肠癌患者SII的危险因素(P<0.05)。经过2年的随访,两组均未出现死亡。术后6个月、术后1年,两组的肿瘤复发率比较,差异无统计学意义(P>0.05);术后1.5、2年,低SII组的肿瘤复发率低于高SII组,差异具有统计学意义(P<0.05)。结论SII对结直肠癌患者的肿瘤病理学特征以及术后复发具有显著的提示意义,值得临床医学工作者借鉴应用。Objective To explore the clinical significance of systemic immune inflammatory index(SII)in patients with colorectal cancer.Methods A retrospective analysis of 122 patients with colorectal cancer admitted from January 2019 to January 2021 was performed.SII was calculated before surgery in all patients.According to the results of SII,the patients were divided into high SII group(n=57)and low SII group(n=65).Multivariate Logistic regression analysis was used to explore the influencing factors of SII in patients with colorectal cancer;all patients were followed up for 2 years,the survival rate and tumor recurrence rate of the high SII group and the low SII group were recorded and compared at 6 months and 1,1.5 and 2 years after operation.Results There were statistically significant differences in Karnofsky Performance Status(KPS)score,carbohydrate antigen 125(CA125)level,tumor diameter,preoperative albuminuria(Alb)level and pathological TNM staging between the two groups(P<0.05).Multivariate Logistic regression analysis result showed that tumor diameter>5 cm,preoperative Alb≤35.00 g/L and pathological TNM stage T_(3)-T_(4) were risk factors for SII in patients with colorectal cancer(P<0.05).After 2 years of follow-up,no death occurred in both groups.At 6 months and 1 year after operation,there was no significant difference in tumor recurrence rate between the two groups(P>0.05);at 1.5 and 2 years after operation,the tumor recurrence rate in the low SII group was lower than that in the high SII group,and the difference was statistically significant(P<0.05).Conclusion SII has significant implications for tumor pathological features and postoperative recurrence of colorectal cancer patients,which is worthy of reference and application by clinical medical workers.

关 键 词：结直肠癌 全身免疫炎症指数 病理学分期 影响因素 复发 

分 类 号：R734.2[医药卫生—肿瘤]