NLRP6炎性小体与炎症性肠病  

NLRP6 Inflammasome and Inflammatory Bowel Disease

作　　者：周淳宇 单静怡 蒋风茹 孙博云 袁建业[1] ZHOU Chunyu;SHAN Jingyi;JIANG Fengru;SUN Boyun;YUAN Jianye(Longhua Hospital Affiliated to Shanghai University of Chinese Medicine/Institute of Spleen and Stomach Diseases,Shanghai Institute of Traditional Chinese Medicine,Shanghai 200032,China)

机构地区：[1]上海中医药大学附属龙华医院/上海市中医药研究院脾胃病研究所,上海200032

出　　处：《陕西中医药大学学报》2024年第4期1-6,共6页Journal of Shaanxi University of Chinese Medicine

基　　金：国家自然科学基金项目(82104743)。

摘　　要：核苷酸结合寡聚化结构域样受体蛋白(Nucleotide-binding oligomerization domain-like receptor protein, NLRP)6炎性小体由NLRP6、胱天蛋白酶-1和凋亡相关斑点样蛋白组成。NLRP6是构成NLRP6炎性小体的核心蛋白,其由氨基端的热蛋白结构域中间的NACHT结构域以及羧基端的富含亮氨酸的重复序列结构域构成。由于NLRP6是较新的炎性小体,其在机体病理生理中的作用的许多细节还有待确定。目前已知NLRP6炎性小体在慢性炎症、自身免疫综合征和代谢性疾病的发展过程中发挥重要作用。炎症性肠病(inflammatory bowel disease, IBD)是与免疫失调密切相关的慢性肠道炎症性疾病,当前已成为在发达国家和发展中国家中广泛存在的全球流行病,但IBD的详细发病机制还有待彻底揭示。逐渐增多的证据显示,NLRP6炎性小体与IBD发病密切相关。文章就目前相关研究进展作一综述。Nucleotide-binding oligomerization domain-like receptor protein(NLRP)6 inflammasomes are composed of NLRP6,caspase-1,and apoptosis related spot like proteins.NLRP6 is the core protein that constitutes the NLRP6 inflammasome,consisting of the NACHT domain in the middle of the hot protein domain at the amino end and the leucine rich repetitive sequence domain at the carboxyl end.Due to NLRP6 being a relatively new inflammasome,many details of its role in the pathophysiology of the body remain to be determined.Currently,it is known that NLRP6 inflammasomes play an important role in the development of chronic inflammation,autoimmune syndrome,and metabolic diseases.Inflammatory bowel disease(IBD)is a chronic inflammatory bowel disease closely related to immune dysfunction,and has become a widely prevalent global epidemic in developed and developing countries.However,the detailed pathogenesis of IBD still needs to be thoroughly revealed.An increasing amount of evidence suggests that NLRP6 inflammasome is closely related to the onset of IBD.The article provides a review of current research progress in related fields.

关 键 词：核苷酸结合寡聚化结构域样受体蛋白6 炎性小体 炎症性肠病 白介素 肠道菌群 

分 类 号：R364.5[医药卫生—病理学]