The pathogenesis of chronic subdural hematoma in the perspective of neomembrane formation and related mechanisms  

作　　者：MINGYUE HUANG JUNFEI DAI XIANLIANG ZHONG JIN WANG JIANZHONG XU BO DU 

机构地区：[1]School of Medicine,Southern University of Science and Technology,Shenzhen,518055,China [2]Department of Emergency,Shenzhen People’s Hospital,The Second Clinical Medical College of Jinan University,The First Affiliated Hospital of Southern University of Science and Technology,Shenzhen,518055,China

出　　处：《BIOCELL》2024年第6期889-896,共8页生物细胞（英文）

基　　金：This research was funded by Guangdong Natural Science Foundation(2020A1515010289);Shenzhen Key Medical Discipline Construction Fund(Shenzhen Key Medical Discipline 2020-2024);Shenzhen Science and Technology Innovation Foundation(Shenzhen Technology Key Project JSGG20211029095400001).

摘　　要：Chronic subdural hematoma(CSDH)is a disease characterized by capsuled blood products that progressively occupy the intracranial space,causing intracranial hypertension and compression in the brain.CSDH frequently occurs in all demographics,especially in the elderly,but the pathogenesis of CSDH remains unclear.In this review,we discuss the origin,development,and current treatment strategies of CSDH.For thefirst time,we analyzed the cellular and molecular compositions of hematoma membranes with a focus on neomembrane formation,a complex early-stage interactive event in hematoma pathogenesis.We hypothesize that in patients with CSDH,dural border cells(DBCs)might be induced to synthesize collagen or serum proteins might accumulate at the dura and arachnoid layers at the site of injury,thereby encapsulating the hemorrhage.Membrane formation may trigger inflammatory responses after subdural hemorrhage,promotingfibroblast-involved extracellular matrix(ECM)deposition and aberrant angiogenesis within the outer membrane.Consequently,ECM deposition and angiogenesis mutually influence each other and are modulated by inflammatory processes.By illustrating the complex and interactive mechanism of neomembrane formation,we aim to provide a novel insight into CSDH pathogenesis and propose directions for future research as well as advancements in treatment strategies for this disease.

关 键 词：Chronic subduralhematoma Inflammation ANGIOGENESIS Extracellular matrix HYPERFIBRINOLYSIS 

分 类 号：R651.1[医药卫生—外科学]