立体定向微创手术治疗对老年脑胶质瘤患者免疫水平及日常生活能力的影响  

Effect of Stereotactic Minimally Invasive Surgery on Immune Level and Activities of Daily Living in Elderly Patients with Glioma

作　　者：王浩然 石长斌[1] 杜文众[1] 杨猛[1] 刘文[1] 邓文佳 Wang Haoran;Shi Changbin;Du Wenzhong;Yang Meng;Liu Wen;Deng Wenjia(The First Affiliated Hospital of Harbin Medical University,Harbin 150001)

机构地区：[1]哈尔滨医科大学附属第一医院,哈尔滨150001

出　　处：《国际老年医学杂志》2024年第4期444-447,共4页International Journal of Geriatrics

基　　金：黑龙江省重点研发计划指导类项目(GZ20210157)。

摘　　要：目的 探究立体定向微创手术治疗对老年脑胶质瘤患者免疫水平及日常生活能力的影响。方法 选取哈尔滨医科大学附属第一医院2020年3月—2022年2月收治的老年胶质瘤患者90例作为研究对象,按照随机数字表法分为两组,各45例。对照组采取常规开颅术瘤切除治疗,观察组采取立体定向微创手术治疗。比较两组的临床疗效、日常生活活动能力量表(ADL)评分、美国国立卫生研究院卒中量表(NIHSS)评分、外周血免疫指标辅助性T细胞(Th)1、Th2以及Th17水平。结果 观察组临床总有效率高于对照组,术后1年复发率低于对照组,治疗后观察组ADL评分高于对照组,NIHSS评分低于对照组,Th1水平高于对照组,Th2及Th17水平低于对照组,差异均有统计学意义(P<0.05)。结论 立体定向微创手术治疗老年脑胶质瘤疗效确切,不仅改善了免疫功能指标及神经功能缺损情况,还有助于提高日常生活能力,降低短期复发率。Objective To investigate the effect of stereotactic minimally invasive surgery on immune level and activities of daily living in elderly patients with glioma.Methods Ninety elderly patients with glioma admitted to the First Affiliated Hospital of Harbin Medical University from March 2020 to February 2022 were selected as the study subjects and divided into two groups according to the random number table,45 cases for each group.The control group was treated with conventional craniotomy and the observation group was treated with stereotactic minimally invasive surgery.The clinical efficacy,activities of daily living(ADL)score,National Institutes of Health Stroke Scale(NIHSS)score,peripheral blood immune parameters T helper(Th)1,Th2 and Th17 levels were compared between the two groups.Results The overall response rate in the observation group was higher than that in the control group.The recurrence rate at 1 year after surgery was lower than that in the control group.After treatment,the ADL score in the observation group was higher than that in the control group,the NIHSS score was lower than that in the control group,the Th1 level was higher than that in the control group,and the Th2 and Th17 levels were lower than those in the control group.The differences were statistically significant(P<0.05).Conclusion Stereotactic minimally invasive surgery is effective in the treatment of glioma in the elderly,not only improving the immune function indicators and neurological deficits,but also helping to improve the activities of daily living,reduceing short-term recurrence rate.

关 键 词：立体定向微创手术 脑胶质瘤 神经功能缺损 日常生活能力 免疫功能 

分 类 号：R739.41[医药卫生—肿瘤]