直肠癌神经浸润的影像评估进展  

Progress of imaging assessment of perineural invasion in rectal cancer

作　　者：何蓉 张义 李盼盼 宋歌声 李爱银[1] 王艺 He Rong;Zhang Yi;Li Panpan;Song Gesheng;Li Aiyin;Wang Yi(Department of Radiology,the First Affiliated Hospital of Shandong First Medical University(Shandong Provincial Qianfoshan Hospital),Jinan 250014,China;CT Room,Zhangqiu District Second People's Hospital,Jinan 250200,China;Medical Imaging Centre,the Central Hospital Affiliated to Shandong First Medical University,Jinan 250013,China)

机构地区：[1]山东第一医科大学第一附属医院(山东省千佛山医院)放射科,济南250014 [2]济南市章丘区第二人民医院CT室,250200 [3]山东第一医科大学附属中心医院医学影像中心,济南250013

出　　处：《中华消化病与影像杂志（电子版）》2024年第4期378-381,共4页Chinese Journal of Digestion and Medical Imageology(Electronic Edition)

基　　金：山东第一医科大学(山东省医学科学院)青年科学基金培育资助计划项目(202201-080)。

摘　　要：直肠癌是严重影响人类生存、生活质量的常见消化道恶性肿瘤之一,T1~2N0直肠癌治疗是以全直肠系膜切除术为主要手段,T3~4或N+患者推荐新辅助治疗。神经浸润(PNI)指肿瘤接近神经并包绕至少33%神经周径或者肿瘤细胞穿透神经鞘三层中的任意一层。PNI是直肠癌重要的生物学特征和预后影响因素,目前只能通过术后病理诊断。不能手术的晚期直肠癌患者在新辅助化疗前,若能通过无创影像手段获取直肠癌PNI状态,将进一步完善患者的个性化诊疗并影响预后。本文对直肠癌PNI的影像学评估的研究进展进行综述。Rectal cancer is one of the common gastrointestinal malignant tumors that seriously affects human survival and quality of life.Total mesorectal excision(TME)is the main method for the treatment of T1-2N0 rectal cancer,and neoadjuvant therapy is recommended for T3-4 or N+patients.Perineural invasion(PNI)refers to the tumor approaching the nerve and wrapping at least 33%of the nerve circumference or the tumor cells penetrating any of the three layers of the nerve sheath.PNI is an important biological feature and prognostic factor of rectal cancer,and its diagnosis can only be confirmed by postoperative pathology.Before neoadjuvant therapy for advanced rectal cancer patients who cannot be operated,if the PNI status of rectal cancer can be obtained by noninvasive imaging means,it will further improve the personalized diagnosis and influence the prognosis of patients.This article reviews the research progress of imaging evaluation of PNI in rectal cancer.

关 键 词：直肠癌 神经浸润 影像评估 

分 类 号：R735.37[医药卫生—肿瘤]