重复经颅磁刺激对精神分裂症患者的影响  

Effects of Repeated Transcranial Magnetic Stimulation on Patients with Schizophrenia

作　　者：于海英 田建华[1] Yu Haiying;Tian Jianhua(Shihezi Oasis Hospital,Shihezi 832000,Xinjiang Uygur Autonomous Region,China)

机构地区：[1]石河子绿洲医院,新疆维吾尔自治区石河子832000

出　　处：《中外医药研究》2024年第15期42-44,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:探讨重复经颅磁刺激对精神分裂症患者的影响。方法:选取2023年1—12月石河子绿洲医院收治的精神分裂症患者60例作为研究对象,以随机数表法分为常规组和试验组,各30例。常规组采用利培酮、认知功能训练治疗,试验组在常规组基础上采用重复经颅磁刺激治疗。比较两组5-羟色胺(5-HT)、去甲肾上腺素(NE)水平,脑电波频率,认知功能[基于修订的韦氏记忆量表(WMS-RC)和威斯康星卡片测验系统(WCST)]。结果:治疗前,两组5-HT、NE水平比较,差异无统计学意义(P>0.05);治疗后,两组5-HT、NE水平低于治疗前,试验组低于常规组,差异有统计学意义(P<0.05)。治疗前,两组β波、θ波和SMR波频率比较,差异无统计学意义(P>0.05);治疗后,两组β波、θ波和SMR波频率高于治疗前,试验组高于常规组,差异有统计学意义(P<0.05)。治疗前,两组WMS-RC、WCST评分比较,差异无统计学意义(P>0.05);治疗后,两组WMS-RC、WCST评分低于治疗前,试验组低于常规组,差异有统计学意义(P<0.05)。结论:重复经颅磁刺激可以调节精神分裂症患者的不良情绪,改善神经功能及认知功能。Objective:To investigate the effect of repeated transcranial magnetic stimulation on patients with schizophrenia.Methods:Sixty patients with schizophrenia admitted to Shihezi Oasis Hospital from January to December 2023 were selected as the research objects,and were divided into conventional group and experimental group by random number table method,with thirty cases in each group.The conventional group was treated with risperidone and cognitive function training,and the experimental group was treated with repeated transcranial magnetic stimulation based on the conventional group.Levels of serotonin(5-HT),norepinephrine(NE),brain wave frequency,and cognitive function[Wechsler Memory Scale-Revised in Chinese(WMS-RC)and the Wisconsin Card Sorting Test(WCST)]were compared between the two groups.Results:Before treatment,there was no significant difference in 5-HT and NE levels between the two groups(P>0.05);after treatment,the levels of 5-HT and NE in two groups were lower than before treatment,and those in experimental group were lower than those in conventional group,the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the frequency ofβwave,θwave and SMR wave between the two groups(P>0.05);after treatment,the frequencies ofβwave,θwave and SMR wave in both groups were higher than before treatment,and those in experimental group were higher than those in conventional group,the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in WMS-RC and WCST scores between the two groups(P>0.05);after treatment,WMS-RC and WCST scores of the two groups were lower than before treatment,and the experimental group was lower than the conventional group,the difference was statistically significant(P<0.05).Conclusion:Repetitive transcranial magnetic stimulation can regulate the negative emotions and improve the neurological and cognitive functions of patients with schizophrenia.

关 键 词：精神分裂症 重复经颅磁刺激 脑电波 神经功能 认知功能 

分 类 号：R749.3[医药卫生—神经病学与精神病学]