T_(1-2)N_(0-1)期乳腺癌ki67表达与临床病理及超声表现的相关性研究  

Correlation Between T_(1-2)N_(0-1) Breast Cancer ki67 and Clinicopathological and Ultrasound Manifestations

作　　者：燕柳屹 裴斐 贾柠瑞 李亚男 潘巧红[1] YAN Liuyi;PEI Fei;JIA Ningrui;LI Yanan;PAN Qiaohong(Department of Ultrasound Medicine,Heping Hospital,Changzhi Medical College)

机构地区：[1]长治医学院附属和平医院超声医学科,山西长治046000

出　　处：《长治医学院学报》2024年第3期203-208,共6页Journal of Changzhi Medical College

摘　　要：目的:评估T_(1-2)N_(0-1)期浸润性乳腺癌分子生物学指标ki67与临床病理及术前超声图像的相关性。方法:选取经病理证实为早期浸润性乳腺癌的女性患者288例,按照ki67不同表达水平将其分为低表达组(≤5%)、高表达组(≥30%)和中间表达组(>5%~<30%)。采用单因素分析其临床病理特征及超声影像学特征与各组的关系,将差异性特征纳入多因素Logistic回归分析。结果:单因素分析显示,3组肿瘤最大径(P=0.001)、肿瘤形态(P<0.001)、肿瘤后方回声衰减(P=0.013)、超声淋巴结形态(P=0.040)比较,差异有统计学意义(P<0.05);多因素分析显示,肿瘤最大径>2 cm(OR=0.517)、肿瘤形态不规则(OR=0.421)、肿瘤后方回声衰减(OR=0.095)及超声淋巴结形态异常(OR=0.498)是ki67高表达的独立危险因素。结论:超声表现与T_(1-2)N_(0-1)期乳腺癌的ki67表达水平具有相关性,其中肿瘤形态最大直径>2 cm、肿瘤形态不规则、肿瘤后方回声衰减及超声淋巴结形态异常的乳腺癌,患者更易出现ki67高表达。Objective:To evaluate the correlation between the molecular biological index ki67 of T_(1-2)N_(0-1) invasive breast cancer and clinicopathological and preoperative ultrasound images.Methods:A total of 288 female patients with pathologically confirming early invasive breast cancer were retrospectively selected and divided into three groups which were low expression group(≤5%),high expression group(≥30%),and intermediate expression group(>5%~<30%)according to different expression levels of ki67.Univariate analysis was employed to examine the association between clinicopathological features and ultrasound imaging features within each group.The distinctive characteristics identified were then included in the multivariate Logistic regression analysis.Results:Univariate analysis revealed significant differences in tumor diameter(P=0.001),mass morphology(P<0.001),echo attenuation behind the mass(P=0.013),and lymph node abnormal(P=0.040)among the three groups(P<0.05).Multivariate analysis revealed that tumor maximum diameter(OR=0.517),mass morphology(OR=0.421),echo attenuation behind the mass(OR=0.095),and ultrasound lymph node morphology(OR=0.498)were independent risk factors associated with varied ki67 expression levels.Conclusion:Ultrasound is correlateel with ki67 expression level in stage T_(1-2)N_(0-1) breast cancer.Poctiencts with breast cancer with maximum diameter greater than 2cm,irregular tumor morphology,echo attenuation behind the tumor,and abnormal ultrasound lymph node morphology are more likely to show high expression of ki67.

关 键 词：乳腺癌 肿瘤生物标志物 超声特征 病理学 KI67 

分 类 号：R737[医药卫生—肿瘤]