不同病理分级腹膜假黏液瘤:^(18)F-FDG PET/CT双时相显像表现及血清肿瘤标志物水平  

Pseudomyxoma peritonei:^(18)-FDG PET/CT dual-phase imaging and serum tumor markers among different pathological grades

作　　者：张丽 李兵[2] 文哲 童冠圣 ZHANG Li;LI Bing;WEN Zhe;TONG Guansheng(Department of Nuclear Medicine,Beijing Shijitan Hospital,Capital Medical University,Beijing 100038,China;Department of Oncology Surgery,Beijing Tsinghua Changgung Hospital,Tsinghua University,Beijing 102218,China)

机构地区：[1]首都医科大学附属北京世纪坛医院核医学科,北京100038 [2]清华大学附属北京清华长庚医院肿瘤外科,北京102218

出　　处：《中国医学影像技术》2024年第6期880-884,共5页Chinese Journal of Medical Imaging Technology

摘　　要：目的对比不同病理分级腹膜假黏液瘤(PMP)^(18)F-FDG PET/CT双时相显像表现及血清肿瘤标志物水平。方法回顾性分析31例经病理确诊阑尾来源PMP患者,根据病理结果分为低级别、高级别及高级别伴印戒细胞PMP。对比不同级别PMP^(18)F-FDG PET/CT常规和延迟显像表现,以及PET/CT检查前1个月内血清癌胚抗原(CEA)、糖类抗原(CA)125及CA 19-9水平。结果31例PMP包括14例低级别、12例高级别及5例高级别伴印戒细胞PMP。^(18)F-FDG PET/CT延迟显像中,低、高级别PMP病灶最大标准摄取值(SUV_(max))、病灶SUV_(max)与肝脏平均标准摄取值之比(SUV_(max)/SUV_(livermean))及PET-腹膜癌指数(PCI)均高于常规^(18)F-FDG PET/CT显像(P均<0.05);延迟显像中,高级别伴印戒细胞PMP病灶SUV_(max)、SUV_(max)/SUV_(livermean)和PET-PCI均与常规显像差异均无统计学意义(P均>0.05)。不同病理分级PMP患者之间,CEA、CA 125及CA 19-9水平差异均无统计学意义(P均>0.05)。结论不同病理分级PMP的^(18)F-FDG PET/CT双时相显像表现具有一定特征性,血清肿瘤标志物水平与PMP病理分级无明显相关。Objective To investigate^(18)-FDG PET/CT dual-phase imaging features and serum tumor marker levels of pseudomyxoma peritonei(PMP)with different pathological grades.Methods A total of 31 patients with pathologically confirmed PMP originated from appendix were retrospectively analyzed.The tumors were divided into low-grade,high-grade and high-grade with signet-ring cell PMP according to pathological results.^(18)-FDG PET/CT conventional and delayed imaging manifestations,as well as serum levels of carcinoembryonic antigen(CEA),carbohydrate antigen(CA)125 and CA 19-9 within 1 month before PET/CT examination were comparatively analyzed among PMP with different pathological grades.Results Among 31 cases,low-grade PMP was found in 14 cases,high-grade PMP in 12 cases while high-grade with signet-ring cell PMP was detected in 5 cases.The maximal standard uptake value(SUV_(max))of PMP lesion,the ratio of SUV_(max) to mean standard uptake value for the liver(SUV_(max)/SUV_(liver mean))and PET-peritoneal cancer index(PCI)of low-and high-grade PMP measured on delayed imaging were all higher than those measured on conventional imaging(all P<0.05).SUV_(max),SUV_(max)/SUV liver mean and PET-PCI of high-grade with sig-ring cell PMP lightly increased on delayed imaging compared with those on conventional imaging,but no significant difference was not(all P>0.05).No statistical difference of serum CEA,CA 125 and CA 19-9 levels was observed among PMP with different pathological grades.Conclusion^(18)-FDG PET/CT dual-phase imaging manifestations of different pathological grades PMP had certain characteristics,while no significant correlation was found between serum tumor marker level and pathological grade of PMP.

关 键 词：假黏液瘤 腹膜 正电子发射断层显像术 肿瘤标记 生物学 

分 类 号：R735.5[医药卫生—肿瘤] R445.6[医药卫生—临床医学]