膜联蛋白A1在脑缺血-再灌注损伤中作用的研究进展  

Advances in the role of annexin A1 in cerebral ischemia-reperfusion injury

作　　者：汤子豪 孙军 Tang Zihao;Sun Jun(the Second Clinical College of Zhejiang Chinese Medical University,Hangzhou 310053,China)

机构地区：[1]浙江中医药大学第二临床医学院,杭州310053 [2]浙江省温州市中心医院泛血管疾病管理中心实验室

出　　处：《中国脑血管病杂志》2024年第6期406-411,共6页Chinese Journal of Cerebrovascular Diseases

摘　　要：脑缺血-再灌注损伤是急性缺血性卒中血管再通治疗过程中继发且不可避免的病理生理变化,可导致神经元受损,影响认知功能和行为功能,甚至发生死亡。炎症反应是导致脑缺血-再灌注损伤的重要机制之一。膜联蛋白A1是一种强大的生理性抗炎症蛋白质,作者对近年来膜联蛋白A1与脑缺血-再灌注损伤的关系进行综述,以期为后续研究提供参考。Cerebral ischemia-reperfusion injury is a secondary and inevitable pathophysiological change in the process of vascular recanalization in acute ischemic stroke,which can lead to neuronal damage,affect cognitive and behavioral functions,and even cause death.Inflammatory response is one of the important mechanisms leading to cerebral ischemia-reperfusion injury.Annexin A1(ANXA1)is a powerful physiological anti-inflammatory protein.The authors reviews the relationship between ANXA1 and cerebral ischemia-reperfusion injury in recent years,in order to provide reference for subsequent research.

关 键 词：膜联蛋白A1 再灌注损伤 炎症 综述 

分 类 号：R743.3[医药卫生—神经病学与精神病学]