西藏地区克氏综合征患者精液及生殖激素水平分析  

Analysis of semen and reproductive hormone levels in patients with Klinefelter syn-drome in Xizang

作　　者：张晓雅 李磊[1] Zhang Xiaoya;Li Lei(Fukang Hospital Affiliated to Tibet University,Lhasa 850000,China)

机构地区：[1]西藏大学附属阜康医院,拉萨850000

出　　处：《西藏科技》2024年第5期36-40,54,共6页Xizang Science And Technology

基　　金：西藏大学附属阜康医院项目(FK202104)。

摘　　要：目的探讨西藏地区克氏综合征患者的精液及生殖激素水平。方法收集在西藏大学附属阜康医院生殖中心确诊的21例克氏综合征患者的临床资料,将染色体核型分析正常的不育患者设为对照组,比较两组年龄、民族、精液质量及生殖激素水平差异。结果克氏综合征患者检出率为0.86%,藏族占比高于对照组,精液质量低于对照组,促卵泡生成素和促黄体生成素水平高于对照组,睾酮水平低于对照组,差异均有统计学意义(均P<0.05),而两组间年龄差异无统计学意义(P>0.05)。结论克氏综合征患者多为无精子症,促性腺激素水平偏高,睾酮水平偏低,需提高该疾病认识,及早诊治,保留生育力。Objective The study is to investigate the levels of semen and reproductive hormones in patients with Klinefelter syndrome in Xizang.Methods The clinical data of 21 patients with Klinefelter syndrome diagnosed in the Reproductive Center of Fukang hospital affiliated to Tibet University were collected.The infertility patients with normal karyotype analysis were set as the control group.The differences in age,ethnicity,semen quality and repro-ductive hormone levels between the two groups were compared.Results The detection rate of patients with Klinefel-ter syndrome was 0.86%,the proportion of Tibetan was higher than that of the control group,the semen quality was lower than that of the control group,the levels of follicle-stimulating hormone and luteinizing hormone were higher than those of the control group,and the levels of testosterone were lower than those of the control group,all of which were statistically significant(all P<0.05),while the age difference between the two groups was not statistically sig-nificant(P>0.05).Conclusions Most patients with Klinefelter syndrome have azoospermia,high gonadotropin lev-els and low testosterone levels,so it is necessary to raise the awareness of the disease,diagnose and treat it early and preserve fertility.

关 键 词：克氏综合征 克兰费尔特综合征 精液质量 生殖激素 生育力 

分 类 号：R698.2[医药卫生—泌尿科学]