老年抑郁障碍患者认知损害的影响因素  

Study on Influencing Factors of Cognitive Impairment in Late-life Depression Patients

作　　者：陶圆佳 程宇琪 晏和智 苏翔宇 陈娴瑜 姜红燕[1] TAO Yuanjia;CHENG Yuqi;YAN Hezhi;SU Xiangyu;CHEN Xianyu;JIANG Hongyan(Dept.of Psychiatry,The 1st Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650031,China)

机构地区：[1]昆明医科大学第一附属医院精神科,云南昆明650031

出　　处：《昆明医科大学学报》2024年第6期94-99,共6页Journal of Kunming Medical University

基　　金：云南省重大科技专项计划基金资助项目(202102AA100058);云南省科技人才与平台计划基金资助项目(院士计划类别:专家工作站)(202305AF150180)。

摘　　要：目的 探究老年抑郁障碍患者认知损害的影响因素。方法 入组2018年1月至2022年9月昆明医科大学第一附属医院精神科住院部老年期抑郁症患者119例,采用蒙特利尔认知评估量表评估认知功能,建立回归模型,分析比较认知损害的影响因素。结果 年龄对认知总分、视觉空间能力和执行功能、语言功能的影响,差异有统计学意义(P <0.05);焦虑的程度对认知总分、视觉空间能力和执行功能、注意力和工作记忆力的影响,差异有统计学意义(P <0.05);血脂水平异常对认知总分、视觉空间能力和执行功能的影响,差异有统计学意义(P <0.05);既往史对认知总分、语言功能的影响,差异有统计学意义(P <0.05);性别、发病年龄、抑郁程度、ApoE基因、职业状态、有无精神病性症状均对个别认知功能的影响,差异有统计学意义(P <0.05)。结论 老年抑郁障碍患者存在明显的认知损害,其中年龄、焦虑程度,血脂水平异常、既往史等因素可能是中老年抑郁障碍患者认知损害的风险因素。Objective To explore the influencing factors of cognitive impairment in elderly patients with depressive disorder.Methods 119 elderly patients with depression were recruited in the 1st Affiliated Hospital of Kunming Medical University.MoCA was used to evaluate the cognitive function of the patients,and a regression model was established to analyze the influencing factors of cognitive impairment in elderly patients with depression.Results Age had a significant effect on the total score of cognition,visuospatial ability,executive function and language function( P < 0.05).The degree of anxiety had a significant effect on the total score of cognition,visuospatial ability,executive function,attention and working memory(P < 0.05).Dyslipidemia had a statistically significant effect on the total score of cognition,visuospatial ability and executive function(P < 0.05).The past medical history had a significant effect on the total score of cognition and language function(P < 0.05).The sex,onset time,degree of depression,ApoE gene,occupation status and psychotic symptoms had statistically significant effects on individual cognitive function( P < 0.05).Conclusion Patients with late-life depressive disorder have obvious cognitive impairment.Age,anxiety,dyslipidemia,and past medical history may be the risk factors for cognitive impairment in elderly patients with depressive disorder.

关 键 词：老年抑郁障碍 认知损害 APOE基因 

分 类 号：R749.4[医药卫生—神经病学与精神病学]