MB-PDT辅助基础治疗对下前牙牙槽骨角形吸收的临床疗效评价  

Clinical effect of MB-PDT assisted initial therapy on alveolar angle absorption of lower anterior teeth

作　　者：卜晓霜 王晓 潘涛华 朱丽雷 郭锦材 BU Xiao-shuang;WANG Xiao;PAN Tiao-hua;ZHU Li-lei;Guo Jin-cai(Department of Periodontology and Oral Mucosal Diseases,Changsha Stomatological Hospital.Changsha 410006;School of Stomatology,Hunan University of Chinese Medicine.Changsha 410006;Department of Pharmacy,Changsha Stomatological Hospital.Changsha 410006,Hunan Province,China)

机构地区：[1]长沙市口腔医院牙周黏膜病科,湖南长沙410006 [2]湖南中医药大学口腔医学院,湖南长沙410006 [3]长沙市口腔医院药剂科,湖南长沙410006

出　　处：《上海口腔医学》2024年第3期265-268,共4页Shanghai Journal of Stomatology

基　　金：湖南省临床医疗技术创新引导项目(2020SK53202,2020SK53206);湖南省自然科学基金(2024JJ9532);湖南省卫生健康委科研计划项目(202313048136);湖南省中医药科研课题(B2023048);湖南中医药大学校院联合基金项目(2022XYLH134)。

摘　　要：目的:评估采用亚甲基蓝光敏剂介导的光动力疗法(methylene blue photodynamic therapy,MB-PDT)辅助基础治疗对改善牙周炎患者下前牙牙槽骨角形吸收的效果。方法:选择2018年4月—2020年10月在长沙市口腔医院牙周黏膜病科确诊为牙周炎第Ⅲ~Ⅳ阶段C级,下前牙牙槽骨角形吸收>37°,牙周袋深度>4 mm的患者40例,对照组和试验组各20例。对照组采用基础治疗,试验组在对照组基础上增加MB-PDT辅助治疗。术前和术后1、2周记录2组患者的菌斑指数(plaque index,PLI)和牙龈出血指数(gingival bleeding index,GBI),术前、术后6个月检测牙周袋深度(probing depth,PD)和临床附着丧失(clinical attachment level,CAL)。采用Graphpad Prism 5软件包对数据进行统计学分析。结果:试验组术后1、2周PLI和GBI均显著低于对照组(P<0.05);术后6个月,试验组患牙的PD和CAL水平显著低于对照组(P<0.05)。结论:MB-PDT辅助基础治疗可降低牙龈炎症,改善牙周炎患者牙周临床指标,是下前牙牙槽骨角形吸收的新型非手术辅助治疗方法。PURPOSE:To evaluate the effect of MB-PDT assisted essential therapy on angle resorption of lower anterior alveolar bone in patients with periodontitis.METHODS:Forty patients who were diagnosed with periodontitis stage III-IV or C,lower anterior teeth alveolar bone angle resorption,and periodontal pocket depth greater than 4 mm were selected from April 2018 to October 2020 in the Department of Periodontology and Oral Mucosal Diseases,Changsha Stomatological Hospital.The patients were randomly divided into control group and experimental group with 20 cases in each group.Compared with the control group which was only managed with essential treatment,the experimental group was treated with MB-PDT on the basis of the control group.The plaque index(PLI)and gingival bleeding index(GBI)scores of the two groups were recorded before surgery and 1 and 2 weeks after surgery.Probing depth(PD)and clinical attachment level(CAL)were detected before and 6 months after surgery.Statistical analysis of the data was performed using Graphpad Prism 5 software package.RESULTS:The PLI and GBI of the experimental group were significantly lower than those of the control group at 1 and 2 weeks after operation(P<0.05).Six months after surgery,PD and CAL levels in the experimental group were significantly lower than those in the control group(P<0.05).CONCLUSIONS:MB-PDT adjuvant therapy has the advantages of simple operation,efficient sterilization,promotion of healing,and high safety performance.It may be a new non-surgical adjuvant treatment strategy for effective treatment of lower anterior alveolar angular resorption.

关 键 词：亚甲基蓝 光动力疗法 基础治疗 牙周炎 牙槽骨角形吸收 

分 类 号：R781.4[医药卫生—口腔医学]