动物生物安全三级模拟实验室的建设与实践探讨  

Analysis of the construction and practice of an animal biosafety level-3 simulated laboratory

作　　者：再那吾东·玉山 李晓燕[1] 鹿双双[1] 王嘉琪 卡力比夏提·艾木拉江 刘美 刘科亮[3] 卢选成[1] ZAINAWUDONG Yushan;LI Xiaoyan;LU Shuangshuang;WANG Jiaqi;KALIBIXIATI Aimulajiang;LIU Mei;LIU Keliang;LU Xuancheng(National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases(NITFID),Chinese Center for Disease Control and Prevention,Beijing 102206,China;State Key Laboratory on Pathogenesis,Prevention and Treatment of High Incidence Diseases in Central Asia,Clinical Medicine Institute,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054;Sichuan Center for Diseases Control and Prevention,Chengdu 610044)

机构地区：[1]传染病溯源预警与智能决策全国重点实验室,中国疾病预防控制中心,北京102206 [2]省部共建中亚高发病因与防治国家重点实验室,新疆医科大学第一附属医院临床医学研究院,乌鲁木齐830054 [3]四川省疾病预防控制中心,成都610044

出　　处：《中国比较医学杂志》2024年第6期87-92,共6页Chinese Journal of Comparative Medicine

基　　金：国家重点研发计划(2022YFC2304302)。

摘　　要：动物生物安全三级实验室(ABSL-3实验室)是可以开展高致病性病原微生物感染实验动物的生物安全防护水平为三级的高级别生物安全实验室。近年来随着新发、再发传染病的不断出现,高级别生物安全实验室在病原致病机理、药物和疫苗研发等方面发挥了越来越重要的硬件支撑作用,ABSL-3实验室的需求与日俱增。与此同时,对于能够胜任ABSL-3实验室工作的人员需求也越来越多,岗前培训的系统化、规范化、标准化成为进入ABSL-3实验室开展工作的人员生物安全的重要保证。ABSL-3实验室的岗前培训工作需要在特定的场所——模拟实验室内开展,因此有必要建立ABSL-3模拟实验室,并建立科学有效的运行标准和机制。本文全面介绍了ABSL-3模拟实验室的设计、建设、运行及作用。An animal biosafety level-3 laboratory(ABSL-3)is a high-level biosafety installation that can conduct experiments on animals infected with highly pathogenic microorganisms.In recent years,with the continuous characterization of emerging and re-emerging infectious diseases,high-level biosafety laboratories have played increasingly important roles in pathogenic mechanism and drug and vaccine research and development.The demand for ABSL-3 is increasing year by year.At the same time,there is also a growing demand for personnel who are competent in working in ABSL-3.The systematization,normalization,and standardization of pre-service training have become important to guarantee a reduction in the risks to personnel working in ABSL-3.Training of ABSL-3 staff needs to be carried out in specific simulated laboratories.Therefore,it is necessary to construct simulated ABSL-3 and establish scientific and effective operating standards and mechanisms.This paper comprehensively introduces the design,construction,operation,and functions of a simulated ABSL-3 installation.

关 键 词：ABSL-3实验室 ABSL-3模拟实验室 实验室获得性感染 生物安全 风险评估 培训 

分 类 号：R-33[医药卫生]