光动力疗法的抗肿瘤免疫效应研究进展  

Research progress on the immune effects of photodynamic therapy

作　　者：侴雯馨 孙天真 顾瑛[1,2] 赵洪友 Chou Wen-Xin;Sun Tian-Zhen;Gu Ying;Zhao Hong-You(School of Medical Technology,Beijing Institute of Technology,Beijing 100081,China;Department of Laser Medicine,the First Medical Center of Chinese PLA General Hospital,Beijing 100853,China)

机构地区：[1]北京理工大学医学技术学院,北京100081 [2]解放军总医院第一医学中心激光医学科,北京100853

出　　处：《解放军医学杂志》2024年第6期718-725,共8页Medical Journal of Chinese People's Liberation Army

基　　金：国家自然科学基金重大项目(T2293750,T2293753);北京理工大学青年教师学术启动计划(XSQD-202023003);中国医学科学院医学与健康科技创新工程(2019-I2M-5-061)。

摘　　要：光动力疗法(PDT)作为一种新兴的肿瘤治疗手段,因不良反应较少、靶向性好、可重复治疗等优点,已被广泛应用于临床多种肿瘤的治疗。相较手术、化疗及放疗等传统治疗策略,PDT不仅可杀伤原位肿瘤,还可通过激活机体的免疫效应对转移瘤发挥抑制作用。然而,PDT诱导免疫效应的高低受多种因素影响,包括光敏剂在细胞内的定位和剂量、光参数、肿瘤内的氧浓度、免疫功能的完整性等。本文对PDT介导抗肿瘤免疫效应的相关机制,以及PDT免疫效应的主要影响因素进行综述,以探讨PDT用于肿瘤治疗的未来发展方向。As a novel tumor treatment,photodynamic therapy(PDT)has been widely used in clinical treatment of a variety of tumors due to its advantages,such as fewer adverse reactions,precise targeting and repeatability of treatment.Unlike conventional treatments,such as surgery,chemotherapy and radiotherapy,PDT not only eliminates the primary tumor but also effectively inhibits metastatic tumors by activating the body's immune response.However,the PDT-activated immune response is influenced by multiple factors,including the localization and dose of photosensitizer in the cells,light parameters,oxygen concentration in the tumor,and the integrity of immune function.This review summarizes the mechanisms behind the PDT-activated anti-tumor immune response,systematically examines the key influencing factors on the immune effect of PDT,and discusses the future development direction of PDT in cancer treatment.

关 键 词：光动力疗法 固有免疫 特异性免疫 影响因素 

分 类 号：R730.57[医药卫生—肿瘤]