Sézary综合征1例  

Sézary Syndrome:A Case Report

作　　者：当增卓玛 陈伟[1] 王琳[1] DANGZENG Zhuoma;CHEN Wei;WANG Lin(Department of Dermatology and Venereology,West China Hospital,Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西医院皮肤性病科,四川成都610041

出　　处：《中国皮肤性病学杂志》2024年第7期803-807,共5页The Chinese Journal of Dermatovenereology

摘　　要：患者男,69岁,全身红斑伴瘙痒11个月余。皮损组织病理示:表皮轻度肥厚,可见淋巴细胞亲表皮,数个Pautrier微脓肿,真皮浅层小血管周围大量淋巴样细胞浸润,其中较多细胞中等偏小、核型不规则。免疫组织化学示:CD2、CD3、CD5、CD4均阳性,CD7、CD8、CD20、CD30、CD68均阴性。诊断:Sézary综合征。A 69-year-old male presented with systemic erythema and pruritus for over 11 months.Pathological examination revealed mild epidermal hypertrophy accompanied by lymphocytic infiltration and the presence of several Pautrier microabscesses.Additionally,there was significant infiltration of lymphoid cells surrounding small blood vessels in the superficial dermis layer,among which many cells exhibited small-to-medium size and irregular karyotype.Immunohistochemistry demonstrated positive expression of CD2,CD3,CD5,and CD4 markers,while negative staining was observed for CD7,CD8,CD20,CD30,and CD68 markers.Based on these findings,Sézary syndrome was diagnosed.

关 键 词：SÉZARY综合征 蕈样霉菌病 淋巴瘤 

分 类 号：R739.5[医药卫生—肿瘤]