肠道菌群在眼科疾病中的研究进展  

Research progress of gut microbiota in ophthalmic diseases

作　　者：沈钱逸(综述) 管怀进[1] 季敏(审校)[1] Shen Qianyi;Guan Huaijin;Ji Min(Department of Ophthalmology,Affiliated Hospital of Nantong University,Nantong 226000,China)

机构地区：[1]南通大学附属医院眼科,南通226000

出　　处：《中华实验眼科杂志》2024年第6期584-586,共3页Chinese Journal Of Experimental Ophthalmology

基　　金：国家自然科学基金(81670852);江苏省卫生健康委科研资助项目(M2021084);南通市科技项目(MS22022020)。

摘　　要：近年来,关于肠道菌群的研究越来越多。多项研究表明,肠道菌群失调在各种疾病的发生和发展中起到关键作用,是多种疾病预防和治疗干预的新靶点。本文就肠道菌群在一些眼部疾病的研究进行综述,包括自身免疫性葡萄膜炎、年龄相关性黄斑变性、糖尿病视网膜病变、原发性开角型青光眼和Sj gren综合征等,其作用机制可能是通过肠道菌群的改变,影响如丁酸盐等微生物代谢物,从而影响肠道上皮细胞屏障;或是肠道菌群介导的免疫反应,最终引起组织损伤。研究肠道菌群失调在眼部疾病发生和发展中的作用可提高对相关疾病发生机制的认识,为进一步探索相关眼病的治疗策略提供新的思路。In recent years,research on gut microbiota has been increasing.Multiple studies have shown that the dysbiosis of gut microbiota plays a key role in the occurrence and development of various diseases,potentially revealing a new target for disease prevention and treatment intervention.This article reviews the role of gut microbiota in the pathogenesis and treatment of ophthalmic diseases,including autoimmune uveitis,age-related macular degeneration,diabetic retinopathy,primary open-angle glaucoma and Sj gren syndrome,etc.The mechanism of ocular tissue damage may be the imbalance of the gut microbiota affects microbial metabolites such as butyrate,which influences the intestinal epithelial cell barrier,or mediates immune responses.Investigating the role of gut microbiota dysbiosis in the development and progression of ocular diseases may improve our understanding of the mechanisms of related diseases.Regulation of the gut microbiota or modulation of the metabolites may be a potential way to treat certain eye diseases.It provides new ideas for further exploration of the pathogenesis and adjuvant treatment of such eye diseases.

关 键 词：肠道菌群 葡萄膜炎 年龄相关性黄斑变性 糖尿病视网膜病变 青光眼 

分 类 号：R77[医药卫生—眼科]