牙周炎与心力衰竭相关性的研究进展  

Progress of research on the correlation between periodontitis and heart failure

作　　者：刘诗礼 赵蕾[1] Liu Shili;Zhao Lei(State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Dept.of Periodontology,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)

机构地区：[1]口腔疾病防治全国重点实验室、国家口腔医学中心、国家口腔疾病临床医学研究中心、四川大学华西口腔医院牙周病科,成都610041

出　　处：《国际口腔医学杂志》2024年第4期425-432,共8页International Journal of Stomatology

基　　金：国家自然科学基金(81970944);四川省自然科学基金(2023NSFSC0553);成都市科技项目(2021-YF05-01864-SN)。

摘　　要：心力衰竭(HF)是各类心脏疾病的严重表现或终末阶段,严重影响患者的身心健康。目前对HF病因学的探索涉及多个方面,炎症对HF进程的影响是学者们关注的热点之一。牙周炎是菌斑生物膜引起的牙周软硬组织破坏性疾病,是常见的口腔疾病之一。已有报道指出牙周炎与心血管疾病(CVD)存在关联,但牙周炎与HF的关系及其机制的研究目前尚处于起步阶段。近年来发现牙周致病菌及其毒性产物可以通过直接和间接途径对心肌功能产生影响,从而影响HF的进程。本文对牙周炎与HF的相关性及其影响机制的研究进展进行综述,以期为牙周炎及CVD的共同防治提供一定的研究思路。Heart failure(HF)is a serious manifestation or terminal stage of various heart diseases,seriously affecting the physical and mental health of patients.Its etiology is explored through many aspects,among which the influence of inflammation on the HF process is a scholarly research hotspot.Periodontitis is a destructive disease of periodontal soft and hard tissues caused by plaque biofilm and is one of the two major oral diseases.Periodontitis is reportedly associated significantly with cardiovascular disease(CVD).The relationship between periodontitis and HF and its mechanism remain in the initial stage of research.Periodontal pathogens and their toxic products can reportedly affect myocardial function directly and indirectly,thereby affecting HF progression.This work provides a review of the progress of research on periodontitis and HF to provide some research ideas for the joint prevention and treatment of periodontitis and CVD.

关 键 词：心力衰竭 牙周炎 心肌重构 心肌细胞 

分 类 号：R783[医药卫生—口腔医学]