小整联蛋白结合配体N端联结糖蛋白家族在硬组织发育中的调控作用  

Role of the small integrin-binding ligand N-linked glycoprotein family in regulating hard tissue development

作　　者：徐思为 李蕙 刘磊[1] Xu Siwei;Li Hui;Liu Lei(State Key Laboratory of Oral Disease&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Dept.of Trauma and Plastic Surgery,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)

机构地区：[1]口腔疾病防治全国重点实验室、国家口腔医学中心、国家口腔疾病临床医学研究中心、四川大学华西口腔医院创伤与整形外科,成都610041

出　　处：《国际口腔医学杂志》2024年第4期505-512,共8页International Journal of Stomatology

基　　金：国家自然科学基金青年科学基金(82100961)。

摘　　要：硬组织发育是生物机体发育过程中的重要组成部分,小整联蛋白结合配体N端联结糖蛋白家族在硬组织发育过程中发挥重要的调控作用,如:促进干细胞的成牙本质分化或成骨分化,调控成牙本质细胞或成骨细胞的基因表达等。编码小整联蛋白结合配体N端联结糖蛋白家族的基因发生突变可引起硬组织矿化异常,导致如低血磷性佝偻病、牙本质发育不全等多种疾病。近年来,学者们对该蛋白家族在硬组织发育中的调控作用开展了深入研究,揭示了该蛋白家族的主要分子调控机制,加深了对其作用及机制的认知。因此,本文对小整联蛋白结合配体N端联结糖蛋白家族在生物硬组织发育中的调控作用及其机制的研究进展进行总结和综述。The development of hard tissue is a crucial aspect of organismic development.The small integrin-binding ligand N-linked glycoprotein family plays a pivotal role in regulating hard tissue development,including promoting the differentiation of stem cells into odontoblasts or osteoblasts and regulating the gene expression of these cells.Research showed that mutations in the genes encoding this protein family can lead to abnormal mineralization of hard tissue,resulting in diseases such as hypophosphatemic rickets and dentinogenesis imperfecta.In recent years,scholars have conducted in-depth research on this protein family involved in hard tissue development.These studies have revealed the main molecular regulatory mechanism of the protein family and deepened our understanding of its role and mechanism.This review summarizes the role and the associated molecular regulatory mechanisms of the small integrin-binding ligand N-linked glycoprotein family in regulating hard tissue development.

关 键 词：小整联蛋白结合配体N端联结糖蛋白家族 硬组织 生物矿化 

分 类 号：R394.1[医药卫生—医学遗传学]