因其他疾病住院的患者院内感染新型冠状病毒后肺炎发病的危险因素  

Risk factors for pneumonia after nosocomial infection of SARS-CoV-2 in patients hospitalized for other diseases

作　　者：王晓晨 林向华[1] 蔡梦珊 彭栩健 钟润锵 吕云娟 罗玲[1] WANG Xiaochen;LIN Xianghua;CAI Mengshan;PENG Xujian;ZHONG Runqiang;LYU Yunjuan;LUO Ling(Clinical Laboratory,The Sun Yat-Sen Memorial Hospital,Sun Yat-Sen University,Guangzhou 510120,China)

机构地区：[1]中山大学孙逸仙纪念医院检验科,广州510120

出　　处：《山东医药》2024年第18期35-39,共5页Shandong Medical Journal

摘　　要：目的分析因其他疾病住院的患者院内感染新型冠状病毒(SARS-CoV-2)后肺炎发病的危险因素。方法275例因其他疾病住院的患者,根据住院期间是否感染SARS-CoV-2后发生肺炎分为肺炎组68例、无肺炎组207例,收集患者临床资料,采用二元Logistic回归分析法分析住院患者感染SARS-CoV-2后发生肺炎的危险因素。结果与无肺炎组相比,肺炎组患者年龄大、男性比例高,患有高血压、糖尿病、心脑血管疾病、神经系统疾病、慢性阻塞性肺疾病、贫血、营养不良、鼻咽癌和肝分化型胚胎瘤比例均高(P均<0.05);与无肺炎组相比,肺炎组患者红细胞分布宽度、白细胞计数、中性粒细胞高,血清尿素、葡萄糖、谷丙转氨酶、谷草转氨酶、总胆红素、γ-谷氨酰转肽酶、碱性磷酸酶、纤维蛋白原和D-二聚体水平高,凝血酶原时间及活化部分凝血活酶时间长,红细胞计数、红细胞比积、血红蛋白、淋巴细胞、嗜酸性粒细胞、嗜碱性粒细胞低,血清钙、总蛋白、白蛋白和胆碱酯酶水平低(P均<0.05)。年龄大、男性、凝血酶原时间延长、嗜碱性粒细胞百分比下降、活化部分凝血活酶时间缩短以及血清总蛋白水平下降为发生肺炎的危险因素(OR分别为1.037、5.383、115.786、0.155、0.884、0.941,P均<0.05)。结论年龄大、男性、凝血酶原时间延长、嗜碱性粒细胞百分比下降、活化部分凝血活酶时间缩短以及血清总蛋白水平降低的因其他疾病住院的患者感染SARS-CoV-2后更易发生肺炎。Objective To analyze risk factors for pneumonia after nosocomial infection of novel coronavirus(SARSCoV-2)in patients hospitalized for other diseases.Methods Totally 275 hospitalized patients for other diseases were di⁃vided into the pneumonia group(n=68)and non-pneumonia group(n=207)according to the development of pneumonia af⁃ter nosocomial infection of SARS-CoV-2,the clinical data of the patients were collected,and binary Logistic regression analysis was used to analyze the risk factors for pneumonia after SARS-CoV-2 infection in patients.Results Compared with the non-pneumonia group,patients in the pneumonia group were older,had a higher proportion of males,had higher proportions of hypertension,diabetes,cardiovascular and cerebrovascular diseases,nervous system diseases,chronic ob⁃structive pulmonary diseases,anemia,malnutrition,nasopharyngeal carcinomas and liver differentiated embryomas(all P<0.05).Compared with the non-pneumonia group,the red blood cell distribution width,white blood cell count and neutro⁃phils were higher,the serum levels of urea,glucose,alanine aminotransferase,aspartate aminotransferase,total biliru⁃bin,γ-glutamyl transpeptidase,alkaline phosphatase,fibrinogen and D-dimer were higher,the levels of prothrombin time and activated partial thromboplastin time were longer,the red blood cell count,hematocrit,hemoglobin,lymphocytes,eo⁃sinophils and basophils were lower,and the serum levels of calcium,total protein,albumin and cholinesterase were lower in the pneumonia group(all P<0.05).Increased age,male gender,prolonged prothrombin time,decreased percentage of basophils,shortened activated partial thromboplastin time and decreased level of serum total protein were risk factors for pneumonia(OR=1.037,5.383,115.786,0.155,0.884,and 0.941,respectively;all P<0.05).Conclusion Pa⁃tients hospitalized for other diseases with older age,male gender,longer prothrombin time,a lower percentage of baso⁃phils,shorter activated partial thromboplastin time and a lower serum total protein leve

关 键 词：院内感染 肺炎 继发性肺炎 新型冠状病毒 年龄 性别 凝血酶原 嗜碱性粒细胞百分比 白蛋白 

分 类 号：R563[医药卫生—呼吸系统]