血清肿瘤标志物联合检测对肺癌患者术后复发的预测价值  

Predictive value of serum tumor markers combined detection for postoperative recurrence of lung cancer patients

作　　者：张静[1] 夏丽娜[1] 朱兵帅 ZHANG Jing;XIA Li’na;ZHU Bingshuai(Department of Laboratory,Luohe Central Hospital,Luohe 462300,He’nan,China)

机构地区：[1]漯河市中心医院检验科,河南漯河4623000

出　　处：《癌症进展》2024年第10期1109-1112,1122,共5页Oncology Progress

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20200893)。

摘　　要：目的 探讨血清肿瘤标志物[癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)、鳞状细胞癌相关抗原(SCC-Ag)、细胞角质蛋白19片段抗原21-1(CYFRA21-1)、胃泌素释放肽前体(ProGRP)]联合检测对肺癌患者术后复发的预测价值。方法 选取110例肺癌患者和110例健康体检者,分别作为观察组和健康组,比较两组受试者、术前和术后1年肺癌患者、复发与未复发肺癌患者术后1年血清CEA、NSE、SCC-Ag、CYFRA21-1、ProGRP水平。绘制受试者工作特征(ROC)曲线,计算曲线下面积(AUC),评估血清CEA、NSE、SCC-Ag、CYFRA21-1、ProGRP单独及联合检测对肺癌患者术后复发的预测价值。结果 观察组患者血清CEA、NSE、SCC-Ag、CYFRA21-1、ProGRP水平均明显高于健康组,差异均有统计学意义(P﹤0.01)。术后1年,肺癌患者血清CEA、NSE、SCC-Ag、CYFRA21-1、ProGRP水平均明显低于术前,差异均有统计学意义(P﹤0.01)。随访1年,110肺癌手术患者中,复发30例,未复发80例,未复发肺癌患者术后1年血清CEA、NSE、SCC-Ag、CYFRA21-1、ProGRP水平均明显低于复发患者,差异均有统计学意义(P﹤0.01)。ROC曲线显示,血清CEA、NSE、SCC-Ag、CYFRA21-1、ProGRP联合检测预测肺癌患者术后复发的AUC为0.930(95%CI:0.875~0.985),灵敏度为85.00%,特异度为93.75%,均高于各指标单独检测。结论 肺癌患者血清CEA、NSE、SCC-Ag、CYFRA21-1、ProGRP水平较高,上述指标联合检测预测肺癌患者术后复发的效能较高。Objective To explore the predictive value of combined detection of serum tumor markers[carcinoembry-onic antigen(CEA),neuron specific enolase(NSE),squamous cell carcinoma antigen(SCC-Ag),cyto-keratin 19 frag-ment antigen 21-1(CYFRA21-1),and pro-gastrin-releasing peptide(ProGRP)]for postoperative recurrence in lung can-cer patients.Method A total of 110 lung cancer patients and 110 healthy subjects were selected as the observation group and the healthy group,respectively.The serum CEA,NSE,SCC-Ag,CYFRA21-1 and ProGRP levels of the two groups of subjects,lung cancer patients before and 1 year after surgery,and recurrent and non-recurrent lung cancer patients at 1 year after surgery were compared.The receiver operating characteristic(ROC)curve was drawn,the area under the curve(AUC)was calculated,and the serum CEA,NSE,SCC-Ag,CYFRA21-1 and ProGRP levels single and combined detec-tion in predicting postoperative recurrence in lung cancer patients were evaluated.Result The serum CEA,NSE,SCC-Ag,CYFRA21-1,and ProGRP levels in the observation group were significantly higher than those of the healthy group,and the differences were statistically significant(P<0.01).At 1 year after surgery,the serum CEA,NSE,SCC-Ag,CY-FRA21-1,and ProGRP levels in lung cancer patients were significantly lower than those before surgery,the differences were statistically significant(P<0.01).During 1-year follow-up,among 110 lung cancer patients who underwent surgery,there were 30 cases of recurrence and 80 cases of non-recurrence.The serum CEA,NSE,SCC-Ag,CYFRA21-1,and ProGRP levels in the non-recurrent lung cancer patients at 1 year after surgery were significantly lower than those of re-current patients,the differences were statistically significant(P<0.01).ROC curve showed that the AUC of serum CEA,NSE,SCC-Ag,CYFRA21-1,and ProGRP combined detection in predicting postoperative recurrence in lung cancer pa-tients was 0.930(95%CI:0.875-0.985),sensitivity was 85.00%,and specificity was 93.75%,which were higher than those single detected of each ind

关 键 词：肺癌 癌胚抗原 神经元特异性烯醇化酶 鳞状细胞癌相关抗原 细胞角质蛋白19片段抗原21-1 胃泌素释放肽前体 复发 

分 类 号：R734.2[医药卫生—肿瘤]