初级纤毛在颞下颌关节骨关节炎软骨退化作用中的研究进展  

Progress of research on the role of primary cilia in cartilage degeneration in temporomandibular joint osteoarthritis

作　　者：李功臣 扈梓悦 孙瑶 LI Gongchen;HU Ziyue;SUN Yao(Shanghai Engineering Research Center of Tooth Restoration and Regeneration,Shanghai 200072,China)

机构地区：[1]上海牙组织修复与再生工程技术研究中心,上海200072 [2]同济大学附属口腔医院口腔颌面外科,上海200072 [3]同济大学附属口腔医院口腔种植科,上海200072

出　　处：《口腔医学》2024年第6期448-451,共4页Stomatology

基　　金：国家自然科学基金(82001070);上海卫生健康委卫生行业临床研究专项(20224Y0197);同济大学自主原创基础研究项目(22120220617)。

摘　　要：颞下颌关节骨关节炎(temporomandibular joint osteoarthritis,TMJOA)的主要病理特征是进行性软骨退化、软骨下骨重塑、滑膜组织的慢性炎症及骨赘形成。软骨细胞凋亡是软骨退化的主要因素之一。TMJOA的预防和治疗可能通过抑制过早或过度的软骨细胞凋亡实现。初级纤毛是突出于软骨细胞表面的细胞器,具有感受力学刺激,诱导软骨细胞活化的作用。研究初级纤毛在TMJ软骨细胞增殖、分化、凋亡中作用,有助于理解TMJOA的发病过程,以制定合理有效的TMJOA治疗策略。Temporomandibular joint osteoarthritis(TMJOA)is characterized by progressive cartilage degeneration,subchondral bone remodeling,chronic inflammation in the synovial tissue and osteophyte formation.Chondrocyte apoptosis is one of the main factors of cartilage degeneration.Prevention and treatment of TMJOA can be achieved by inhibiting premature or excessive chondrocyte apoptosis.Primary cilia protruding from the surface of chondrocytes can sense mechanical stimulation and induce chondrocyte differentiation.Studying the role of primary cilia in TMJOA will help us understand the pathogenesis of TMJOA and construct a reasonable and effective treatment strategy.

关 键 词：颞下颌关节 骨关节炎 软骨退化 软骨细胞 初级纤毛 

分 类 号：R782.6[医药卫生—口腔医学]