CA125、CYFRA21-1、AFR水平与晚期非小细胞肺癌化疗预后的关系  

Relationship between CA125,CYFRA21⁃1,AFR levels and prognosis of advanced non⁃small cell lung cancer treated with chemotherapy

作　　者：周宗正 潘刚[1] 乙楠 张子龙 李心忠 ZHOU Zongzheng;PAN Gang;YI Nan;ZHANG Zilong;LI Xinzhong(Department of Oncology,Suixi County Hospital,Suixi,Anhui,China,235100;Department of Oncology,Huaibei Hospital Affiliated to Bengbu Medical University,Huaibei,Anhui,China,235000)

机构地区：[1]安徽省濉溪县医院肿瘤内一科,安徽濉溪235100 [2]蚌埠医科大学附属淮北医院肿瘤一科,安徽淮北235000

出　　处：《分子诊断与治疗杂志》2024年第6期1019-1023,共5页Journal of Molecular Diagnostics and Therapy

基　　金：2021年度安徽省卫生健康委科研项目(AHWJ2021b044)。

摘　　要：目的 探讨糖链抗原125(CA125)、细胞角蛋白19片段(CYFRA21-1)、白蛋白与纤维蛋白原比值(AFR)水平与晚期非小细胞肺癌化疗预后的关系。方法 选取2019年6月至2023年6月濉溪县医院肿瘤内科收治的晚期非小细胞肺癌患者102例为实验组,另选取同期本院肺部良性病变者67例为对照组,比较两组CA125、CYFRA21-1、AFR水平,实验组经化疗随访3个月后根据实体瘤疗效标准将其分为缓解组66例和未缓解组36例,比较两组患者病理特征及CA125、CYFRA21-1、AFR水平,并采用多因素Logistics回归和ROC曲线分析CA125、CYFRA21-1、AFR与晚期非小细胞肺癌化疗预后的关系及预测价值。结果 实验组AFR水平显著低于对照组,差异有统计学意义(t=10.365,P<0.05),CA125、CYFRA21-1高于对照组,差异有统计学意义(t=20.063,23.479,P<0.05);缓解组肿瘤最大径、TNM分期、组织学分级、淋巴结转移患者所占比例高于缓解组,差异均有统计学意义(χ^(2)=4.0196,8.302,7.312,4.408,P<0.05),CA125、CYFRA21-1均高于为缓解组,差异均有统计学意义(t=7.022,6.016,P<0.05),AFR水平低于未缓解组,差异有统计学意义(t=5.347,P<0.05);肿瘤最大径、组织学分级、TNM分期及CA125、CYFRA21-1、AFR均是影响晚期非小细胞肺癌化疗预后的危险因素(P<0.05);CA125、CYFRA21-1、AFR三者联合预测预后价值相较于单独检测价值更高(AUC=0.985,P<0.05)。结论 CA125、CYFRA21-1及AFR均是影响晚期非小细胞肺癌化疗预后的危险因素,与晚期非小细胞肺癌化疗预后密切相关,三者联合预测具有较好的预测效能。Objective To investigate the relationship between glycochain antigen 125(CA125),cytokeratin-19 fragment(CYFRA21-1),albumin-to-fibrinogen ratio(AFR)and prognosis of advanced non-small cell lung cancer.Methods A total of 102 patients with advanced non-small cell lung cancer admitted to the Medical Oncology Department of Suixi County Hospital from June 2019 to June 2023 were selected as the experimental group,and 67 patients with benign lung lesions in Suixi County hospital during the same period were selected as the control group.The levels of CA125,CYFRA21-1 and AFR were compared between the two groups.The experimental group was divided into a response group of 66 cases and a non-response group of 36 cases based on the efficacy criteria of solid tumors after 3 months of chemotherapy follow-up.The pathologi-cal characteristics,CA125,CYFRA21-1 and AFR levels of the two groups were compared.Multi-factor logis-tics regression and ROC curve analysis were used to analyze the relationship and predictive value of CA125,CYFRA21-1,AFR and chemotherapy prognosis of advanced non-small cell lung cancer.Results AFR level in the experimental group was significantly lower than that in the control group,the difference was statistically sig-nificant(t=10.365,P<0.05),CA125 and CYFRA21-1 were higher than that in the control group,the differ-ence was statistically significant(t=20.063,23.479,P<0.05).The proportion of patients with maximum tumor diameter,TNM stage,histological grade and lymph node metastasis in the remission group was higher than that in the unmitigated group,with statistical significance(χ^(2)=4.0196,8.302,7.312,4.408,P<0.05),and CA125 and CYFRA21-1 were higher than those in the remission group.The difference was statistically significant(t=7.022,6.016,P<0.05),and the AFR levels were lower than those in the unmitigated group,the difference was statistically significant(t=5.347,P<0.05).Tumor maximum diameter,histological grade,TNM stage,CA125,CYFRA21-1 and AFR were all risk factors for the prognosis of advanced NSCLC

关 键 词：非小细胞肺癌 晚期 CA125 CYFRA21-1 AFR 预后 

分 类 号：R734.2[医药卫生—肿瘤]