血清Neu5Ac、S100A1水平与急性心源性脑梗死患者病情、预后的关系  

Relationship between serum Neu5Ac and S100A1 levels and the condition and prognosis of cases with acute cardiogenic cerebral embolism

作　　者：张东[1] 李玲[2] 张然[1] 刘亚丽[3] 张颖 王艳红[1] 韦海燕[4] 李勇[1] 侯书敏[1] 黄晶[1] 栢静 ZHANG Dong;LI Ling;ZHANG Ran;LIU Yali;ZHANG Ying;WANG Yanhong;WEI Haiyan;LI Yong;HOU Shumin;HUANG Jing;BAI jing(Department of Neurology,Chengde Central Hospital,Chengde,Hebei,China,067000;Health Examination Center,Chengde Central Hospital,Chengde,Hebei,China,067000;Department of Cardiology,the Second Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei,China,067000;Department of Rehabilitation Medicine,Chengde Central Hospital,Chengde,Hebei,China,067000;Pharmacy Center,Chengde Central Hospital,Chengde,Hebei,China,067000)

机构地区：[1]承德市中心医院神经内科,河北承德067000 [2]承德市中心医院健康体检中心,河北承德067000 [3]河北北方学院附属第二医院心内一科,河北张家口067000 [4]承德市中心医院康复医学科,河北承德067000 [5]承德市中心医院药学中心,河北承德067000

出　　处：《分子诊断与治疗杂志》2024年第6期1066-1069,1074,共5页Journal of Molecular Diagnostics and Therapy

基　　金：河北省医学科学研究课题计划(20200498);承德市科学技术研究与发展计划项目(202109A022)。

摘　　要：目的 探讨血清N-乙酰神经氨酸(Neu5Ac)、S100钙结合蛋白质A1(S100A1)水平与急性心源性脑梗死患者病情、预后的关系。方法 选取2021年9月至2023年9月承德市中心医院收治的165例急性心源性脑梗死患者,根据梗死面积将患者分为小/中面积组(梗死直径≤4 cm,97例)和大面积组(梗死直径>4 cm,68例);根据美国国立卫生研究院卒中量表(NIHSS)评分将患者分为低NIHSS组(NIHSS<16分,108例)和高NIHSS组(NIHSS≥16分,57例)。检测患者Neu5Ac、S100A1水平,根据患者出院后3个月mRS评分将其分为预后不良组(n=41)和预后良好组(n=124)。采用Pearson相关法探讨血清Neu5Ac、S100A1与脑梗死面积、NIHSS评分的关系,采用多因素logistic回归分析影响因素。结果小/中面积组Neu5Ac、S100A1水平低于大面积组,差异有统计学意义(P<0.05)。低NIHSS组Neu5Ac、S100A1水平低于高NIHSS组,差异有统计学意义(P<0.05)。血清Neu5Ac、S100A1与脑梗死面积、NIHSS评分均呈正相关(均P<0.001)。预后良好组血清Neu5Ac、S100A1低于预后不良组,差异有统计学意义(P<0.05)。预后良好组梗死面积大面积比例、入院NIHSS评分低于预后不良组,差异有统计学意义(P<0.05)。梗死面积大面积、入院NIHSS评分≥15.33分、Neu5Ac≥274.58 ng/mL、S100A1≥5.08 ng/mL是急性心源性脑梗死患者预后危险因素(P<0.05)。结论 血清Neu5Ac、S100A1与急性心源性脑梗死患者脑梗死面积、NIHSS评分有关,有望作为预测患者病情及预后的潜在标记物。Objective To investigate the relationship between serum N-acetylneuramic acid(Neu5Ac)and S100 calcium-binding protein A1(S100A1)and the condition and prognosis of cases with acute cardiogenic cerebral embolism(ACCE).Methods A total of 165 cases with ACCE admitted to Chengde Cen-tral Hospital from September 2021 to September 2023 were selected.For this study,the cases were divided into two groups based on infarction size:a small/medium area group(97 cases with infarction diameter≤4 cm)and a large area group(68 cases with infarction diameter>4 cm).Additionally,based on NIHSS score,108 cases were categorized into a low NIHSS group(NIHSS<16)and 57 cases into a high NIHSS group(NIHSS≥16).The levels of Neu5Ac and S100A1 in the ACCE cases were measured.After 3 monthspost-discharge,the cases were further divided into a poor prognosis group(n=41)and a good prognosis group(n=124)based on their mRS scores.Pearson correlation was used to investigate the relationship between serum Neu5Ac,S100A1,in-farct size,and NIHSS score.Prognostic factors were evaluated using multivariate logistic regression.Results Serum levels of Neu5Ac and S100A1 in the small/medium area group were lower than those in the large area group(P<0.05).The serum levels of Neu5Ac and S100A1 in the low NIHSS group were lower than those in the high NIHSS group(P<0.05).Serum Neu5Ac and S100A1 were positively correlated with cerebral infarction size and NIHSS score(P<0.001).The serum Neu5Ac and S100A1 levels in cases with ACCE in the good prog-nosis group were lower compared to the poor prognosis group(P<0.05).The proportion of large infarct area and NIHSS score in the good prognosis group were also lower compared to the poor prognosis group(P<0.05).The large infarct size,NIHSS score at admission≥15.33,Neu5Ac≥274.58 ng/mL,and S100A1≥5.08 ng/mL were identified as risk factors for poor prognosis in cases with ACCE(P<0.05).Conclusion Serum Neu5Ac and S100A1 are associated with the size of cerebral infarction and NIHSS score in patients with ACCE.They may b

关 键 词：N-乙酰神经氨酸 S100钙结合蛋白质A1 急性心源性脑梗死 

分 类 号：R743.33[医药卫生—神经病学与精神病学]