短暂性脑缺血发作患者血清ox-LDL、sdLDL-C水平及其临床意义  

Levels and clinical significance of serum ox⁃LDL and sdLDL⁃C in patients with transient ischemic attack

作　　者：尚雪峰 王娟[1] 张鹏轩[1] SHANG Xuefeng;WANG Juan;ZHANG Pengxuan(Department of Neurology,Yan'an University Affiliated Hospital,Yan'an,Shaanxi,China,716000)

机构地区：[1]延安大学附属医院神经内科,陕西延安716000

出　　处：《分子诊断与治疗杂志》2024年第6期1161-1164,共4页Journal of Molecular Diagnostics and Therapy

基　　金：陕西省重点研发计划项目(22SF-223)。

摘　　要：目的 探究短暂性脑缺血发作(TIA)患者血清氧化性低密度脂蛋白(ox-LDL)、小而密低密度脂蛋白胆固醇(sdLDL-C)水平及其临床意义。方法 选取2021年4月至2022年9月延安大学附属医院收治的216例短暂性脑缺血发作(TIA)患者设为观察组,根据ABCD-3评分将观察组患者分为低危组(n=77)、中危组(n=93)和高危组(n=46),另选同期入院的健康体检者150名为对照组。对比两组以及观察组不同ABCD-3评分患者血清ox-LDL、sdLDL-C水平;采用Pearson相关系数分析血清ox-LDL、sdLDL-C水平与ABCD3评分的相关性;发病后随访患者1年,根据是否发生缺血性脑卒中(AIS)将观察组患者分为AIS组(n=43)和非AIS组(n=173),比较两组血清ox-LDL、sdLDL-C水平;采用受试者工作曲线分析血清ox-LDL、sdLDL-C水平对TIA患者进展为AIS的预测价值。结果 观察组血清血清ox-LDL、sdLDL-C水平显著高于对照组,差异有统计学意义(P<0.05);血清ox-LDL、sdLDL-C水平:低危组<中危组<高危组,差异有统计学意义(P<0.05);Pearson相关系数分析显示,TIA患者血清ox-LDL、sdLDL-C水平与ABCD-3评分呈显著正相关(P<0.05);AIS组血清ox-LDL、sdLDL-C水平显著高于非AIS组,差异有统计学意义(P<0.05);ROC曲线分析显示,血清ox-LDL、sdLDL-C水平单独及联合预测TIA患者进展为AIS的敏感度为0.791、0.814、0.954,特异度为0.751、0.636、0.624,AUC为0.789、0.792、0.872。结论 TIA患者血清ox-LDL、sdLDL-C水平均呈高表达,且与患者病情显著相关,二指标对TIA患者进展为AIS具有较高的预测价值。Objective To explore the levels and clinical significance of serum oxidized low density lipoprotein(ox-LDL)and small dense low density lipoprotein cholesterol(sdLDL-C)in patients with transient ischemic attack(TIA).Methods 216 patients with TIA at Yanan University Affiliated Hospital from April 2021 to September 2022 were enrolled in the observation group.Based on the ABCD-3 score,the patients in the observation group were classified into the low-risk group(n=77),the middle-risk group(n=93)and the high-risk group(n=46).150 healthy subjects who underwent physical examinations during the same period were se-lected as the control group.The levels of serum ox-LDL and sdLDL-C were compared between the two groups and among patients with different ABCD-3 scores in the observation group.Pearson correlation coefficient was used to analyze the correlation between serum ox-LDL and sdLDL-C levels and ABCD-3 score.The patients in the observation group were followed up for 1 year after disease onset and were divided into the AIS group(n=43)and the non-AIS group(n=173)based on the presence or absence of acute ischemic stroke(AIS).Serum levels of ox-LDL and sdLDL-C were compared.Receiver operating curve was applied to analyze the predictive value of serum ox-LDL and sdLDL-C levels on progression of TIA patients to AIS.Results Serum levels of ox-LDL and sdLDL-C in the observation group were significantly higher than those in the control group(P<0.05).The levels of serum ox-LDL and sdLDL-C were manifested as low-risk group<middle-risk group<high-risk group(P<0.05).Pearson correlation coefficient analysis showed that the levels of serum ox-LDL and sdLDL-C in patients with TIA were significantly positively correlated with the ABCD-3 score(P<0.05).The lev-els of serum ox-LDL and sdLDL-C were significantly higher in the AIS group than in the non-AIS group(P<0.05).ROC curve analysis revealed that the sensitivities of serum ox-LDL and sdLDL-C levels alone and in com-bination to predict the progression of TIA patients to AIS were 0.791,0

关 键 词：短暂性脑缺血发作 氧化性低密度脂蛋白 小而密低密度脂蛋白胆固醇 

分 类 号：R743.31[医药卫生—神经病学与精神病学]