聚集诱导发光荧光分析法在多领域中的应用  

Application of Fluorescence Analysis Method Based on Aggregation Induced Emission in Multi-field

作　　者：曹宇奇 宗军 李璐 张发荣 刘炳光[1] 王晓轲 刘国良 卢俊锋 CAO Yu-qi;ZONG Jun;LI Lu;ZHANG Fa-rong;LIU Bing-guang;WANG Xiao-ke;LIU Guo-liang;LU Jun-feng(School of Biological and Environmental Engineering,Tianjin Vocational Institute,Tianjin 300410,China;Tianjin Zhongke Chemical Co.,Ltd.,Tianjin 300455,China)

机构地区：[1]天津职业大学生物与环境工程学院,天津300410 [2]天津中科化工有限公司,天津300455

出　　处：《分析测试学报》2024年第7期1063-1075,共13页Journal of Instrumental Analysis

摘　　要：荧光分析法是基于对待测物的荧光测量建立起来的方法,具有灵敏度高、选择性好以及响应迅速等优点。作为荧光材料的一种,环境刺激响应型荧光材料因在化学传感、生物成像、压力传感、信息存储、光电器件以及药物传递等领域的广阔应用而展现出良好的前景。但是,大多数传统的荧光剂易受到聚集诱导猝灭效应(ACQ)的影响,严重限制了其实际应用。聚集诱导发光材料(AIE)是近年来开发的一种新型荧光材料,该材料在分散状态下具有较弱的荧光发射,而在聚集状态下发射出强烈荧光。AIE材料的出现有效克服了传统荧光剂聚集诱导猝灭的难题,其独特的光稳定性、高荧光量子产率以及可调控性也为荧光分析检测提供了新的思路和方案。该文综述了聚集诱导发光荧光分析法在生物医药、化学检测、公共安全以及食品与农业等多领域中的研究进展,并对目前存在的问题进行了总结和展望。Fluorescence analysis is an analytical method established based on fluorescence measure⁃ment of analyte as it provides high sensitivity,good selectivity and rapid responsibility.As a kind of fluorescent materials,environmental stimuli responsive fluorescent materials display promising pros⁃pects by virtue of their wide practical applications in chemical sensing,bio-imaging,pressure sens⁃ing,information storage,photoelectronic devices and drug delivery etc.However,most of these flu⁃orophores suffer from a troublesome“aggregation caused quenching”(ACQ)effect,which severely inhibit their applications in practical situations.As a new type of fluorescent material developed in re⁃cent years,aggregation induced emission materials(AIE)emit extremely weak fluorescence in dis⁃persed state but intense fluorescence as aggregates form.The emergence of AIE materials discovered as a remedy to overcome the aggregation caused quenching effect ingrained in traditional fluoro⁃phores.Besides,unique photostability,high fluorescence quantum yield and controllability also provide new ideas for fluorescence analysis.This article reviews the research progress of fluorescence analysis concerning AIE in biomedicine,chemical detection,public security accompanied with food and agriculture,and looks forward to challenges and future directions of research in this field.

关 键 词：聚集诱导发光 生物医药 化学分析 公共安全 食品 

分 类 号：O657.3[理学—分析化学]