光动力疗法在胆管癌诊疗中作用机制研究进展  

Progress in the mechanism of photodynamic therapy in the diagnosis and treatment of cholangiocarcinoma

作　　者：齐硕 陈康 周磊[1] 刘昌军[1] 田秉璋[1] 彭创[1] 成伟[1,2] QI Shuo;CHEN Kang;ZHOU Lei;LIU Changjun;TIAN Binzhang;PENG Chuang;CHENG Wei(Department of Hepatobiliary Surgery,Hunan Provincial People's Hospital(The First Affiliated Hospital of Hunan Normal University),Changsha 410005,China;Xiangyue Hospital Affiliated to Hunan Institute of Parasitic Diseases,Yueyang 414000,China)

机构地区：[1]湖南省人民医院(湖南师范大学附属第一医院)肝胆外科,湖南长沙410005 [2]湖南省血吸虫病防治所(湖南省第三人民医院),湖南岳阳414000

出　　处：《分子影像学杂志》2024年第6期661-664,共4页Journal of Molecular Imaging

基　　金：湖南省教育厅科学研究优秀青年项目(22B0421);湖南省自然科学基金项目(2022JJ40400);湖南省卫生健康委卫生科研课题(W20243022);湖南省教育厅一般项目(23C0025);湖南省教育厅科学研究重点项目(21A0258,21A0026);湖南省普通高等学校教学改革研究项目(HNJG-2022-0738);湖南省社会科学成果评审委员会课题(XSP22YBC146)。

摘　　要：胆管癌是一种罕见但危险的肿瘤,具有早期诊断率低、预后不良等特点,临床上手术切除是根治胆管癌的有效手段,但术后复发率高,而放化疗、介入治疗疗效尚不尽满意。光动力疗法利用光敏剂和激光进行肿瘤治疗,在胆管癌应用中已取得了初步成效,但关于光动力疗法对癌细胞的作用机制还需要深入研究。本文通过对光动力疗法在胆管癌治疗中免疫治疗、血管生成抑制、抗氧化剂及热休克蛋白等机制,以及对光动力疗法联合靶向药物/放射治疗联合作用做一综述,旨在为临床上胆管癌的治疗提供理论依据参考,以期为临床上胆管癌的综合治疗提供安全、有效的治疗手段。Cholangiocarcinoma is a rare but dangerous tumor with low early diagnosis rate and poor prognosis.Surgical resection is an effective method for radical treatment of cholangiocarcinoma,but the postoperative recurrence rate is high.However,the curative effect of radiotherapy,chemotherapy and interventional therapy is not yet satisfactory.Photodynamic therapy,utilizes photosensitizers and laser for tumor treatment,has achieved initial results in the application of cholangiocarcinoma,but further research is needed on the mechanism of photodynamic therapy on cancer cells.This article reviewed the mechanism of photodynamic therapy in the treatment of cholangiocarcinoma and discusses the mechanisms of immunotherapy,angiogenesis inhibition,antioxidants and heat shock proteins.Subsequently,the combined effects of photodynamic therapy combined with targeted drugs/radiation therapy was explored to provide theoretical basis for clinical treatment of cholangiocarcinoma,aiming to provide safe and effective therapeutic measures for cholangiocarcinoma in clinical practice.

关 键 词：光动力疗法 胆管癌 诊断 作用机制 进展 

分 类 号：R735.8[医药卫生—肿瘤]