中药天然产物代谢活化的化学性质可能与其毒性相关  

Chemical nature of metabolic activation of natural products in traditional Chinese medicines possibly associated with toxicities

作　　者：刘雨阳 王旭[2] 刘明璐 郝瑕苓 彭缨[3] 郑江 Yuyang Liu;Xu Wang;Minglu Liu;Xialing Hao;Ying Peng;Jiang Zheng(School of Traditional Chinese Materia Medica,Shenyang Pharmaceutical University,Shenyang,China;School of Pharmacy,Shenyang Pharmaceutical University,Shenyang,China;Wuya College of Innovation,Shenyang Pharmaceutical University,Shenyang,China;State Key Laboratory of Functions and Applications of Medicinal Plants,Key Laboratory of Pharmaceutics of Guizhou Province,Guizhou Medical University,Guiyang,China)

机构地区：[1]沈阳药科大学中药学院 [2]沈阳药科大学药学院 [3]沈阳药科大学无涯创新学院 [4]贵州医科大学药用植物功能与应用国家重点实验室,贵州省药物制剂重点实验室

出　　处：《Acupuncture and Herbal Medicine》2024年第2期184-196,I0006,共14页针灸和草药（英文）

摘　　要：确保中药(TCM)的安全性一直是医疗保健领域中长期存在的普遍挑战。对天然产品的毒理学复杂性进行细致的研究至关重要,特别是这些物质的代谢转化以及随后产生的反应性中间体。这一生化过程是多种毒性表现的起源,包括肝毒性、肾毒性、肺毒性和遗传毒性。在TCM中分类的化合物,包括吡咯里西啶生物碱、蒽醌、呋喃萜类、烯基苯、双苄基异喹啉生物碱、黄酮类和甲氧基二苯基衍生物,在代谢激活后表现出一系列有害机制。这篇综述提供了这些化合物通过代谢激活引起毒性的途径的全面描述。这篇综述强调了天然产物代谢激活中涉及的化学机制,这些机制可能触发毒性级联反应,而不仅仅是表面现象。此外,这项研究通过深入探讨代谢激活引起的毒性机制,丰富了现有文献。总之,这篇综述强调了仔细研究毒性机制的重要性,并为合理和安全使用中药提供了见解。Ensuring the safety of traditional Chinese medicines(TCM)has perennially presented a universal challenge in the healthcare realm.Meticulous investigations into the toxicological intricacies of natural products are of paramount significance,particularly regarding the metabolic transformation of these substances and the subsequent generation of reactive intermediates.This biochemical process underlies the genesis of diverse toxic manifestations,including hepatotoxicity,nephrotoxicity,pulmonary toxicity,and genotoxicity.Compounds sorted within TCM,including pyrrolizidine alkaloids,anthraquinones,furanoterpenoids,alkenylbenzenes,bisbenzylisoquinoline alkaloids,flavonoids,and methylenedioxyphenyl derivatives,evince a spectrum of deleterious mechanisms upon metabolic activation.This review provides a comprehensive delineation of the pathways through which these compounds induce toxicity via metabolic activation.This review emphasizes the chemical mechanisms involved in the metabolic activation of natural products that may trigger a toxic cascade,rather than a superficial phenomenon.Furthermore,this study enriches the extant literature by delving into advancements in elucidating the mechanisms of toxicity engendered by metabolic activation.In conclusion,this review highlights the importance of scrutinizing the mechanisms of toxicity and provides insights into the judicious and safe use of TCM.

关 键 词：医疗保健领域 代谢转化 毒性机制 代谢活化 天然产物 吡咯里西啶生物碱 表面现象 肾毒性 

分 类 号：R284[医药卫生—中药学]